Melt-Extrusion Additive Manufacturing for Tissue Engineering: Applications and Limitations

Andrea Roberto Calore, Carlos Mota, Katrien Bernaerts, Jules Harings, Lorenzo Moroni*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The application of additive manufacturing techniques has increased over the years in almost all production fields, thanks to the possibility of creating objects from scratch and with the desired shape, with no need for molds or complex machinery typical of subtractive manufacturing. This success has concerned the biomedical world as well, where melt-based methods represent the golden standard to produce scaffolds for hard-tissue engineering. Despite the large number of studies present in the literature on scaffold production, the fabrication process is still affected by drawbacks and limitations, which hinders the standardization and upscaling to the industrial level. In this review, we briefly present the history of additive manufacturing and the reasons of its success, with particular reference to the tissue engineering and regenerative medicine world. We then proceed to highlight the current factors limiting the straightforwardness of the production process and affecting the quality and the performance of the manufactured scaffolds. Eventually, we suggest potential strategies to increase the level of control during manufacturing and to improve the biomimicry of the fabricated constructs, with the goal of obtaining a more optimal workflow.
Original languageEnglish
Number of pages19
Journal3D Printing and Additive Manufacturing
DOIs
Publication statusE-pub ahead of print - 1 Jul 2024

Keywords

  • additive manufacturing
  • tissue engineering
  • scaffolds
  • melt-extrusion
  • MESENCHYMAL STEM-CELLS
  • COMPOSITE SCAFFOLDS
  • SURFACE-ROUGHNESS
  • POLYMER SCAFFOLDS
  • POLYCAPROLACTONE SCAFFOLDS
  • 3-DIMENSIONAL SCAFFOLDS
  • PROCESSING PARAMETERS
  • THERMAL-DEGRADATION
  • FABRICATION METHOD
  • MOLECULAR-WEIGHT

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