Melatonin is drug that regulates the sleep-wake rhythm. This dissertation studied the working of melatonin in individuals with intellectual disabilities who have long-term sleep problems. In their case, namely, sleep problems are often caused by a disorder in their own melatonin rhythm; in individuals without intellectual disabilities other factors (such as stress) often play a role. Melatonin not only turned out effective in the treatment of problems with falling asleep and continuing to sleep, but it also had a positive effect on behaviour problems during the day. Aggressive behaviour, such as hitting, biting and destroying, was reduced. Remarkably, in some patients the sleep problems recurred during the treatment after a few weeks because the melatonin was too slowly broken down. The advice is to only start a melatonin treatment after (in the saliva) the moment has been determined when the own melatonin production has started.
|Qualification||Doctor of Philosophy|
|Award date||29 Sep 2010|
|Place of Publication||Utrecht|
|Publication status||Published - 1 Jan 2010|
- individuals with intellectual disabilities
- sleep problems
- behaviour problems