OBJECTIVE: The present study investigated the effectiveness of a newly developed 3-week self-compassion group intervention for enhancing resilience and well-being among female college students. METHOD: Fifty-two students were randomly assigned to either an intervention designed to teach skills of self-compassion (n = 27) or an active control group intervention in which general time management skills were taught (n = 25). Both interventions comprised 3 group meetings held over 3 weeks. To measure resilience and well-being gains, participants filled out a number of questionnaires before and after the intervention. RESULTS: Results showed that the self-compassion intervention led to significantly greater increases in self-compassion, mindfulness, optimism, and self-efficacy, as well as significantly greater decreases in rumination in comparison to the active control intervention. Whereas both interventions increased life satisfaction and connectedness, no differences were found for worry and mood. CONCLUSION: These findings suggest that a brief self-compassion intervention has potential for improving student resilience and well-being.