TY - JOUR
T1 - Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention
T2 - The Food4Me Study
AU - San-Cristobal, Rodrigo
AU - Navas-Carretero, Santiago
AU - Livingstone, Katherine M.
AU - Celis-Morales, Carlos
AU - Macready, Anna L.
AU - Fallaize, Rosalind
AU - O'Donovan, Clare B.
AU - Lambrinou, Christina P.
AU - Moschonis, George
AU - Marsaux, Cyril F. M.
AU - Manios, Yannis
AU - Jarosz, Miroslaw
AU - Daniel, Hannelore
AU - Gibney, Eileen R.
AU - Brennan, Lorraine
AU - Drevon, Christian A.
AU - Gundersen, Thomas E.
AU - Gibney, Mike
AU - Saris, Wim H. M.
AU - Lovegrove, Julie A.
AU - Grimaldi, Keith
AU - Parnell, Laurence D.
AU - Bouwman, Jildau
AU - Van Ommen, Ben
AU - Mathers, John C.
AU - Alfredo Martinez, J.
PY - 2017/10
Y1 - 2017/10
N2 - Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months. Several genetic variants related to metabolic risk features were also analysed. A Genetic Risk Score (GRS) was derived from risk alleles and a Mediterranean Diet Score (MDS), based on validated food intake data, was estimated. At baseline, there were no interactions between GRS and MDS categories for metabolic traits. Linear mixed model repeated measures analyses showed a significantly greater decrease in total cholesterol in participants with a low GRS after a 6-month period, compared to those with a high GRS. Meanwhile, a high baseline MDS was associated with greater decreases in Body Mass Index (BMI), waist circumference and glucose. There also was a significant interaction between GRS and the MedDiet after the follow-up period. Among subjects with a high GRS, those with a high MDS evidenced a highly significant reduction in total carotenoids, while among those with a low GRS, there was no difference associated with MDS levels. These results suggest that a higher MedDiet adherence induces beneficial effects on metabolic outcomes, which can be affected by the genetic background in some specific markers.
AB - Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months. Several genetic variants related to metabolic risk features were also analysed. A Genetic Risk Score (GRS) was derived from risk alleles and a Mediterranean Diet Score (MDS), based on validated food intake data, was estimated. At baseline, there were no interactions between GRS and MDS categories for metabolic traits. Linear mixed model repeated measures analyses showed a significantly greater decrease in total cholesterol in participants with a low GRS after a 6-month period, compared to those with a high GRS. Meanwhile, a high baseline MDS was associated with greater decreases in Body Mass Index (BMI), waist circumference and glucose. There also was a significant interaction between GRS and the MedDiet after the follow-up period. Among subjects with a high GRS, those with a high MDS evidenced a highly significant reduction in total carotenoids, while among those with a low GRS, there was no difference associated with MDS levels. These results suggest that a higher MedDiet adherence induces beneficial effects on metabolic outcomes, which can be affected by the genetic background in some specific markers.
KW - Food4Me study
KW - Mediterranean diet
KW - genetic risk
KW - obesity
KW - BODY-MASS INDEX
KW - RANDOMIZED CONTROLLED-TRIAL
KW - GENOME-WIDE ASSOCIATION
KW - VIRGIN OLIVE OIL
KW - CORONARY-HEART-DISEASE
KW - WEIGHT-LOSS DIET
KW - METABOLIC SYNDROME
KW - PERSONALIZED NUTRITION
KW - WAIST CIRCUMFERENCE
KW - EUROPEAN ADULTS
U2 - 10.3390/nu9101107
DO - 10.3390/nu9101107
M3 - Article
C2 - 29019927
VL - 9
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 10
M1 - 1107
ER -