Mechanotransduction is a context-dependent activator of TGF-β signaling in mesenchymal stem cells

Steven Vermeulen; Nadia Roumans; Floris Honig; Aurélie Carlier; Dennie G A J Hebels; Aysegul Dede Eren; Peter Ten Dijke; Aliaksei Vasilevich; Jan de Boer

doi:10.1016/j.biomaterials.2020.120331

Mechanotransduction is a context-dependent activator of TGF-β signaling in mesenchymal stem cells

Steven Vermeulen, Nadia Roumans, Floris Honig, Aurélie Carlier, Dennie G A J Hebels, Aysegul Dede Eren, Peter Ten Dijke, Aliaksei Vasilevich, Jan de Boer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	120331
Number of pages	14
Journal	Biomaterials
Volume	259
DOIs	https://doi.org/10.1016/j.biomaterials.2020.120331
Publication status	Published - Nov 2020

Keywords

Actin dynamics
Biomaterials
Mesenchymal stem cells
Scleraxis
Mechanobiology
TGF-beta
GROWTH-FACTOR-BETA
SERUM RESPONSE FACTOR
SMOOTH-MUSCLE ACTIN
PROTEIN-KINASE-C
BONE MORPHOGENETIC PROTEIN-2
TENOGENIC DIFFERENTIATION
GENE-EXPRESSION
MECHANICAL FORCE
MATRIX-STIFFNESS
MYOSIN-II

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@article{9a02839bcbc847dabd85494653bcec62,

title = "Mechanotransduction is a context-dependent activator of TGF-β signaling in mesenchymal stem cells",

keywords = "Actin dynamics, Biomaterials, Mesenchymal stem cells, Scleraxis, Mechanobiology, TGF-beta, GROWTH-FACTOR-BETA, SERUM RESPONSE FACTOR, SMOOTH-MUSCLE ACTIN, PROTEIN-KINASE-C, BONE MORPHOGENETIC PROTEIN-2, TENOGENIC DIFFERENTIATION, GENE-EXPRESSION, MECHANICAL FORCE, MATRIX-STIFFNESS, MYOSIN-II",

author = "Steven Vermeulen and Nadia Roumans and Floris Honig and Aur{\'e}lie Carlier and Hebels, {Dennie G A J} and Eren, {Aysegul Dede} and Dijke, {Peter Ten} and Aliaksei Vasilevich and {de Boer}, Jan",

note = "Copyright {\textcopyright} 2020. Published by Elsevier Ltd.",

year = "2020",

month = nov,

doi = "10.1016/j.biomaterials.2020.120331",

language = "English",

volume = "259",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "ELSEVIER SCI LTD",

}

Mechanotransduction is a context-dependent activator of TGF-β signaling in mesenchymal stem cells. / Vermeulen, Steven ; Roumans, Nadia; Honig, Floris; Carlier, Aurélie ; Hebels, Dennie G A J ; Eren, Aysegul Dede; Dijke, Peter Ten; Vasilevich, Aliaksei; de Boer, Jan.

In: Biomaterials, Vol. 259, 120331, 11.2020.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Mechanotransduction is a context-dependent activator of TGF-β signaling in mesenchymal stem cells

AU - Vermeulen, Steven

AU - Roumans, Nadia

AU - Honig, Floris

AU - Carlier, Aurélie

AU - Hebels, Dennie G A J

AU - Eren, Aysegul Dede

AU - Dijke, Peter Ten

AU - Vasilevich, Aliaksei

AU - de Boer, Jan

PY - 2020/11

Y1 - 2020/11

KW - Actin dynamics

KW - Biomaterials

KW - Mesenchymal stem cells

KW - Scleraxis

KW - Mechanobiology

KW - TGF-beta

KW - GROWTH-FACTOR-BETA

KW - SERUM RESPONSE FACTOR

KW - SMOOTH-MUSCLE ACTIN

KW - PROTEIN-KINASE-C

KW - BONE MORPHOGENETIC PROTEIN-2

KW - TENOGENIC DIFFERENTIATION

KW - GENE-EXPRESSION

KW - MECHANICAL FORCE

KW - MATRIX-STIFFNESS

KW - MYOSIN-II

U2 - 10.1016/j.biomaterials.2020.120331

DO - 10.1016/j.biomaterials.2020.120331

M3 - Article

C2 - 32836056

VL - 259

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

M1 - 120331

ER -