@inproceedings{8f13732cc0ab4e3a8c6830110c8cb047,
title = "Mechano-Chemical Interactions in Cardiac Sarcomere Shortening",
abstract = "Tension development in the cardiac sarcomere is highly cooperative, yet the mechanism is not known. We have developed the MechChem model of sarcomere mechanics, which incorporates a mechano-chemical interaction-based cooperativity mechanism in which the thin filament has an intrinsic chemical cooperativity that is boosted by mechanical tension in the thin filament.. In the current study, we extend the MechChem model to include the possibility for the sarcomere to change length when contracting against different afterloads. The model was tested at various afterloads and compared to experimental data. The MechChem model successfully reproduced isotonic twitch experiments.",
keywords = "DEPENDENT CHANGES, COOPERATIVE ACTIVATION, MUSCLE, TROPONIN, CALCIUM",
author = "L.J. Dupuis and J. Lumens and T. Arts and T. Delhaas",
year = "2018",
month = sep,
doi = "10.22489/CinC.2018.274",
language = "English",
isbn = "9781728109589",
volume = "45",
series = "Computing in Cardiology Conference",
publisher = "IEEE",
booktitle = "Computing in Cardiology Conference, CinC 2018",
address = "United States",
note = "45th Computing in Cardiology Conference (CinC) ; Conference date: 23-09-2018 Through 26-09-2018",
}