Mechanisms of weight regain after weight loss - the role of adipose tissue

Marleen A. van Baak*, Edwin C. M. Mariman

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

53 Citations (Web of Science)

Abstract

One of the biggest challenges in the management of obesity is the prevention of weight regain after successful weight loss. Weight regain after weight loss has large interindividual variation. Although many factors probably contribute to this variation, we hypothesize that variability in biological responses associated with weight loss-induced shrinking of subcutaneous adipocytes has an important role. In this Review, we show that weight loss-induced variations in cellular stress, extracellular matrix remodelling, inflammatory responses, adipokine secretion and lipolysis seem to be associated with the amount of weight that is regained after successful weight loss. Weight regain could therefore, at least in part, depend on a combination of these factors. Further research on the causality of these associations could aid the development of effective strategies to prevent weight regain after successful weight loss.

Original languageEnglish
Pages (from-to)274-287
Number of pages14
JournalNature Reviews Endocrinology
Volume15
Issue number5
DOIs
Publication statusPublished - May 2019

Keywords

  • LOW-CALORIE-DIET
  • FATTY-ACID UPTAKE
  • Y GASTRIC BYPASS
  • LOW-ENERGY DIET
  • GENE-EXPRESSION
  • LOSS MAINTENANCE
  • BODY-WEIGHT
  • EXTRACELLULAR-MATRIX
  • INSULIN SENSITIVITY
  • PHYSICAL-ACTIVITY

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