Mechanisms of Drug Induced Liver Injury: Toxicogenomics studies in differint in vitro models

Research output: ThesisDoctoral ThesisInternal

Abstract

Drug-induced liver injury (DILI) is a severe health condition that may result in morbidity and mortality. It adds financial burden on families and healthcare systems. It is not clear what happens, on the molecular level, during DILI. Through comparing genome-wide expression changes in different cell models associated with exposures to DILI-causing agents, we depict the molecular mechanisms of mitochondrial damage and alterations in ceramide metabolism during DILI development. Using a 3D co-cultured model, we also demonstrate the interactions between hepatocytes and Kupffer cells during the inflammation-associated increase in drug toxicity. Our findings would help the development of more sensitive biomarkers that provide early and sensitive detection/diagnosis of DILI.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • de Kok, Theodorus, Supervisor
  • Kleinjans, Joseph, Supervisor
  • Jennen, Danyel, Advisor
Award date25 Oct 2017
Publication statusPublished - 2017

Keywords

  • liver injury
  • toxicogenomics

Cite this

@phdthesis{8342e612ae9142a8856fabe8dbc2703e,
title = "Mechanisms of Drug Induced Liver Injury: Toxicogenomics studies in differint in vitro models",
abstract = "Drug-induced liver injury (DILI) is a severe health condition that may result in morbidity and mortality. It adds financial burden on families and healthcare systems. It is not clear what happens, on the molecular level, during DILI. Through comparing genome-wide expression changes in different cell models associated with exposures to DILI-causing agents, we depict the molecular mechanisms of mitochondrial damage and alterations in ceramide metabolism during DILI development. Using a 3D co-cultured model, we also demonstrate the interactions between hepatocytes and Kupffer cells during the inflammation-associated increase in drug toxicity. Our findings would help the development of more sensitive biomarkers that provide early and sensitive detection/diagnosis of DILI.",
keywords = "liver injury, toxicogenomics",
author = "Jian Jiang",
year = "2017",
language = "English",
school = "Maastricht University",

}

TY - THES

T1 - Mechanisms of Drug Induced Liver Injury

T2 - Toxicogenomics studies in differint in vitro models

AU - Jiang, Jian

PY - 2017

Y1 - 2017

N2 - Drug-induced liver injury (DILI) is a severe health condition that may result in morbidity and mortality. It adds financial burden on families and healthcare systems. It is not clear what happens, on the molecular level, during DILI. Through comparing genome-wide expression changes in different cell models associated with exposures to DILI-causing agents, we depict the molecular mechanisms of mitochondrial damage and alterations in ceramide metabolism during DILI development. Using a 3D co-cultured model, we also demonstrate the interactions between hepatocytes and Kupffer cells during the inflammation-associated increase in drug toxicity. Our findings would help the development of more sensitive biomarkers that provide early and sensitive detection/diagnosis of DILI.

AB - Drug-induced liver injury (DILI) is a severe health condition that may result in morbidity and mortality. It adds financial burden on families and healthcare systems. It is not clear what happens, on the molecular level, during DILI. Through comparing genome-wide expression changes in different cell models associated with exposures to DILI-causing agents, we depict the molecular mechanisms of mitochondrial damage and alterations in ceramide metabolism during DILI development. Using a 3D co-cultured model, we also demonstrate the interactions between hepatocytes and Kupffer cells during the inflammation-associated increase in drug toxicity. Our findings would help the development of more sensitive biomarkers that provide early and sensitive detection/diagnosis of DILI.

KW - liver injury

KW - toxicogenomics

M3 - Doctoral Thesis

ER -