Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion

Nicola M. Blythe, Katsuhiko Muraki, Melanie J. Ludlow, Vasili Stylianidis, Hamish T. J. Gilbert, Elizabeth L. Evans, Kevin Cuthbertson, Richard Foster, Joe Swift, Jing Li, Mark J. Drinkhill, Frans A. van Nieuwenhoven, Karen E. Porter, David J. Beech, Neil A. Turner*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)17395-17408
Number of pages14
JournalJournal of Biological Chemistry
Volume294
Issue number46
DOIs
Publication statusPublished - 15 Nov 2019

Keywords

  • ion channel
  • calcium
  • p38 MAPK
  • mitogen-activated protein kinase (MAPK)
  • IL-6
  • fibroblast
  • heart
  • mechanotransduction
  • patch clamp
  • signal transduction
  • cardiac fibroblast
  • PROLIFERATION
  • DYSFUNCTION
  • FIBROSIS

Cite this

Blythe, N. M., Muraki, K., Ludlow, M. J., Stylianidis, V., Gilbert, H. T. J., Evans, E. L., Cuthbertson, K., Foster, R., Swift, J., Li, J., Drinkhill, M. J., van Nieuwenhoven, F. A., Porter, K. E., Beech, D. J., & Turner, N. A. (2019). Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion. Journal of Biological Chemistry, 294(46), 17395-17408. https://doi.org/10.1074/jbc.RA119.009167