TY - JOUR
T1 - Mechanical Properties of Bioengineered Corneal Stroma
AU - Formisano, Nello
AU - van der Putten, Cas
AU - Grant, Rhiannon
AU - Sahin, Gozde
AU - Truckenmuller, Roman K.
AU - Bouten, Carlijn V. C.
AU - Kurniawan, Nicholas A.
AU - Giselbrecht, Stefan
N1 - Funding Information:
N.F., C.v.d.P., and R.G. contributed equally to this work. Funding sources: This work was supported by the Chemelot InSciTe (project BM3.02).
Publisher Copyright:
© 2021 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH
PY - 2021/10
Y1 - 2021/10
N2 - For the majority of patients with severe corneal injury or disease, corneal transplantation is the only suitable treatment option. Unfortunately, the demand for donor corneas greatly exceeds the availability. To overcome shortage issues, a myriad of bioengineered constructs have been developed as mimetics of the corneal stroma over the last few decades. Despite the sheer number of bioengineered stromas developed , these implants fail clinical trials exhibiting poor tissue integration and adverse effects in vivo. Such shortcomings can partially be ascribed to poor biomechanical performance. In this review, existing approaches for bioengineering corneal stromal constructs and their mechanical properties are described. The information collected in this review can be used to critically analyze the biomechanical properties of future stromal constructs, which are often overlooked, but can determine the failure or success of corresponding implants.
AB - For the majority of patients with severe corneal injury or disease, corneal transplantation is the only suitable treatment option. Unfortunately, the demand for donor corneas greatly exceeds the availability. To overcome shortage issues, a myriad of bioengineered constructs have been developed as mimetics of the corneal stroma over the last few decades. Despite the sheer number of bioengineered stromas developed , these implants fail clinical trials exhibiting poor tissue integration and adverse effects in vivo. Such shortcomings can partially be ascribed to poor biomechanical performance. In this review, existing approaches for bioengineering corneal stromal constructs and their mechanical properties are described. The information collected in this review can be used to critically analyze the biomechanical properties of future stromal constructs, which are often overlooked, but can determine the failure or success of corresponding implants.
KW - bioengineering
KW - corneas
KW - mechanical properties
KW - stromal layers
KW - RECOMBINANT HUMAN COLLAGEN
KW - CROSS-LINKED COLLAGEN
KW - BIOMECHANICAL PROPERTIES
KW - BACTERIAL CELLULOSE
KW - KERATOCYTE PHENOTYPE
KW - ARTIFICIAL CORNEA
KW - SILK FIBROIN
KW - IN-VIVO
KW - ELECTROSPUN COLLAGEN
KW - ROSE-BENGAL
U2 - 10.1002/adhm.202100972
DO - 10.1002/adhm.202100972
M3 - (Systematic) Review article
C2 - 34369098
SN - 2192-2640
VL - 10
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 20
M1 - 2100972
ER -