Mechanical Efficiency in Chronic Obstructive Pulmonary Disease

Willem Gosens*, Alex J. van't Hul, Joost M. Oomen, Matthijs K. C. Hesselink, Lars B. Borghouts

*Corresponding author for this work

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Abstract

PURPOSE: The primary aims of this study were (1) to evaluate whole-body mechanical efficiency (ME) in a large group of chronic obstructive pulmonary disease (COPD) patients with a wide range of degrees of illness and (2) to examine how ME in COPD is related to absolute work rate and indices of disease severity during exercise testing.

METHODS: A total of 569 patients (301 male patients; GOLD stage I: 28, GOLD stage II: 166, GOLD stage III: 265, and GOLD stage IV: 110) with chronic obstructive pulmonary disease (COPD) were included in the data analysis. Individual maximal workload (watt), peak minute ventilation (V-E, L/min body temperature and pressure, saturated), and peak oxygen uptake (VO2, mL/min standard temperature and pressure, dry) were determined from a maximal incremental cycle ergometer test. Ventilatory and metabolic response parameters were collected during a constant work rate test at 75% of the individual maximal workload. From the exercise responses of the constant work rate test, the gross ME was calculated.

RESULTS: The mean whole-body gross ME was 11.0 +/- 3.5% at 75% peak power. The ME declined significantly (P

CONCLUSIONS: Gross ME in COPD was largely predicted by the absolute work rate (r =.87; P

Original languageEnglish
Pages (from-to)146-153
Number of pages8
JournalJournal of Cardiopulmonary Rehabilitation and Prevention
Volume37
Issue number2
DOIs
Publication statusPublished - Mar 2017

Keywords

  • COPD
  • exercise test
  • mechanical efficiency
  • CYCLING EFFICIENCY
  • VASTUS LATERALIS
  • LUNG-FUNCTION
  • EXERCISE
  • MUSCLE
  • HYPERINFLATION
  • COST
  • METAANALYSIS
  • PERFORMANCE

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