TY - JOUR
T1 - Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study
AU - Brink, M.
AU - Weijenberg, M.P.
AU - de Goeij, A.F.
AU - Roemen, G.M.J.M.
AU - Lentjes, M.H.F.M.
AU - de Bruine, A.P.
AU - Goldbohm, R.A.
AU - van den Brandt, P.A.
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 448 colon and 160 rectal cancers that occurred during 7.3 years of follow-up, excluding the first 2.3 years, and 2948 subcohort members of The Netherlands Cohort Study on diet and cancer. Adjusted incidence rate ratios and 95% confidence intervals were computed for colon and rectal cancer and for K-ras mutation status subgroups. Total fresh meat, most types of fresh meat and fish were not associated with colon or rectal cancer, neither overall nor with K-ras mutation status. However, several weak associations were observed for tumours with a wild-type K-ras, including beef and colon tumours, and an inverse association for pork with colon and rectal tumours; for meat products, an increased association was observed with wild-type K-ras tumours in the colon and possibly with G>A transitions in rectal tumours.
AB - Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 448 colon and 160 rectal cancers that occurred during 7.3 years of follow-up, excluding the first 2.3 years, and 2948 subcohort members of The Netherlands Cohort Study on diet and cancer. Adjusted incidence rate ratios and 95% confidence intervals were computed for colon and rectal cancer and for K-ras mutation status subgroups. Total fresh meat, most types of fresh meat and fish were not associated with colon or rectal cancer, neither overall nor with K-ras mutation status. However, several weak associations were observed for tumours with a wild-type K-ras, including beef and colon tumours, and an inverse association for pork with colon and rectal tumours; for meat products, an increased association was observed with wild-type K-ras tumours in the colon and possibly with G>A transitions in rectal tumours.
U2 - 10.1038/sj.bjc.6602491
DO - 10.1038/sj.bjc.6602491
M3 - Article
C2 - 15812479
SN - 0007-0920
VL - 92
SP - 1310
EP - 1320
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 7
ER -