Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study

M. Brink, M.P. Weijenberg, A.F. de Goeij, G.M.J.M. Roemen, M.H.F.M. Lentjes, A.P. de Bruine, R.A. Goldbohm, P.A. van den Brandt

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Abstract

Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 448 colon and 160 rectal cancers that occurred during 7.3 years of follow-up, excluding the first 2.3 years, and 2948 subcohort members of The Netherlands Cohort Study on diet and cancer. Adjusted incidence rate ratios and 95% confidence intervals were computed for colon and rectal cancer and for K-ras mutation status subgroups. Total fresh meat, most types of fresh meat and fish were not associated with colon or rectal cancer, neither overall nor with K-ras mutation status. However, several weak associations were observed for tumours with a wild-type K-ras, including beef and colon tumours, and an inverse association for pork with colon and rectal tumours; for meat products, an increased association was observed with wild-type K-ras tumours in the colon and possibly with G>A transitions in rectal tumours.
Original languageEnglish
Pages (from-to)1310-1320
JournalBritish Journal of Cancer
Volume92
Issue number7
DOIs
Publication statusPublished - 1 Jan 2005

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