Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study

M. Brink, M.P. Weijenberg*, A.F. de Goeij, G.M.J.M. Roemen, M.H.F.M. Lentjes, A.P. de Bruine, R.A. Goldbohm, P.A. van den Brandt

*Corresponding author for this work

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Abstract

Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 448 colon and 160 rectal cancers that occurred during 7.3 years of follow-up, excluding the first 2.3 years, and 2948 subcohort members of The Netherlands Cohort Study on diet and cancer. Adjusted incidence rate ratios and 95% confidence intervals were computed for colon and rectal cancer and for K-ras mutation status subgroups. Total fresh meat, most types of fresh meat and fish were not associated with colon or rectal cancer, neither overall nor with K-ras mutation status. However, several weak associations were observed for tumours with a wild-type K-ras, including beef and colon tumours, and an inverse association for pork with colon and rectal tumours; for meat products, an increased association was observed with wild-type K-ras tumours in the colon and possibly with G>A transitions in rectal tumours.
Original languageEnglish
Pages (from-to)1310-1320
JournalBritish Journal of Cancer
Volume92
Issue number7
DOIs
Publication statusPublished - 1 Jan 2005

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