Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer

J. M. Genkinger; K. Wu; M. Wang; D. Albanes; A. Black; P. A. van den Brandt; K. A. Burke; M. B. Cook; S. M. Gapstur; G. G. Giles; E. Giovannucci; G. G. Goodman; P. J. Goodman; N. Hakansson; T. J. Key; S. Mannisto; L. Le Marchand; L. M. Liao; R. J. MacInnis; M. L. Neuhouser; E. A. Platz; N. Sawada; J. M. Schenk; V. L. Stevens; R. C. Travis; S. Tsugane; K. Visvanathan; L. R. Wilkens; A. Wolk; S. A. Smith-Warner

doi:10.1016/j.annonc.2019.09.007

Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer

J. M. Genkinger^*, K. Wu, M. Wang, D. Albanes, A. Black, P. A. van den Brandt, K. A. Burke, M. B. Cook, S. M. Gapstur, G. G. Giles, E. Giovannucci, G. G. Goodman, P. J. Goodman, N. Hakansson, T. J. Key, S. Mannisto, L. Le Marchand, L. M. Liao, R. J. MacInnis, M. L. NeuhouserE. A. Platz, N. Sawada, J. M. Schenk, V. L. Stevens, R. C. Travis, S. Tsugane, K. Visvanathan, L. R. Wilkens, A. Wolk, S. A. Smith-Warner

^*Corresponding author for this work

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Abstract

Background: Advanced prostate cancer etiology is poorly understood. Few studies have examined associations of anthropometric factors (e.g. early adulthood obesity) with advanced prostate cancer risk.

Patients and methods: We carried out pooled analyses to examine associations between body fatness, height, and prostate cancer risk. Among 830 772 men, 51 734 incident prostate cancer cases were identified, including 4762 advanced (T4/N1/M1 or prostate cancer deaths) cases, 2915 advanced restricted (same as advanced, but excluding localized cancers that resulted in death) cases, 9489 high-grade cases, and 3027 prostate cancer deaths. Cox proportional hazards models were used to calculate study-specific hazard ratios (HR) and 95% confidence intervals (CI); results were pooled using random effects models.

Results: No statistically significant associations were observed for body mass index (BMI) in early adulthood for advanced, advanced restricted, and high-grade prostate cancer, and prostate cancer mortality. Positive associations were shown for BMI at baseline with advanced prostate cancer (HR = 1.30, 95% CI = 0.95-1.78) and prostate cancer mortality (HR = 1.52, 95% CI = 1.12-2.07) comparing BMI >= 35.0 kg/m(2) with 21-22.9 kg/m(2). When considering early adulthood and baseline BMI together, a 27% higher prostate cancer mortality risk (95% CI = 9% to 49%) was observed for men with BMI = 30.0 kg/m(2) at baseline compared with BMI = 110 cm with = 1.00 with = 1.90 m with

Conclusion: Our findings suggest that height and total and central adiposity in mid-to-later adulthood, but not early adulthood adiposity, are associated with risk of advanced forms of prostate cancer. Thus, maintenance of healthy weight may help prevent advanced prostate cancer.

Original language	English
Pages (from-to)	103-114
Number of pages	12
Journal	Annals of Oncology
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/j.annonc.2019.09.007
Publication status	Published - Jan 2020

Keywords

BMI
CAROTENE
COHORT
MASS INDEX
OBESITY
OVERDIAGNOSIS
PHYSICAL-ACTIVITY
POOLED ANALYSIS
SIZE
SUPPLEMENT USE
WEIGHT CHANGE
body fatness
height
pooled analysis
prostate cancer
waist
ANTHROPOMETRY

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1 Erratum / corrigendum / retractions

Corrigendum to ‘Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer’ [Annals of Oncology Volume 31, Issue 1, January 2020, Pages 103-114]
Genkinger, J. M., Wu, K., Wang, M., Albanes, D., Black, A., van den Brandt, P. A., Burke, K. A., Cook, M. B., Gapstur, S. M., Giles, G. G., Giovannucci, E., Goodman, G. G., Goodman, P. J., Hakansson, N., Key, T. J., Mannisto, S., Le Marchand, L., Liao, L. M., MacInnis, R. J., Neuhouser, M. L., & 10 othersPlatz, E. A., Sawada, N., Schenk, J. M., Stevens, V. L., Travis, R. C., Tsugane, S., Visvanathan, K., Wilkens, L. R., Wolk, A. & Smith-Warner, S. A., 1 Sept 2021, In: Annals of Oncology. 32, 9, p. 1201-1201 1 p.
Research output: Contribution to journal › Erratum / corrigendum / retractions › Academic

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Genkinger, J. M., Wu, K., Wang, M., Albanes, D., Black, A., van den Brandt, P. A., Burke, K. A., Cook, M. B., Gapstur, S. M., Giles, G. G., Giovannucci, E., Goodman, G. G., Goodman, P. J., Hakansson, N., Key, T. J., Mannisto, S., Le Marchand, L., Liao, L. M., MacInnis, R. J., ... Smith-Warner, S. A. (2020). Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer. Annals of Oncology, 31(1), 103-114. https://doi.org/10.1016/j.annonc.2019.09.007

@article{71af509ff0274f7a8a75950c3e217068,

title = "Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer",

abstract = "Background: Advanced prostate cancer etiology is poorly understood. Few studies have examined associations of anthropometric factors (e.g. early adulthood obesity) with advanced prostate cancer risk.Patients and methods: We carried out pooled analyses to examine associations between body fatness, height, and prostate cancer risk. Among 830 772 men, 51 734 incident prostate cancer cases were identified, including 4762 advanced (T4/N1/M1 or prostate cancer deaths) cases, 2915 advanced restricted (same as advanced, but excluding localized cancers that resulted in death) cases, 9489 high-grade cases, and 3027 prostate cancer deaths. Cox proportional hazards models were used to calculate study-specific hazard ratios (HR) and 95% confidence intervals (CI); results were pooled using random effects models.Results: No statistically significant associations were observed for body mass index (BMI) in early adulthood for advanced, advanced restricted, and high-grade prostate cancer, and prostate cancer mortality. Positive associations were shown for BMI at baseline with advanced prostate cancer (HR = 1.30, 95% CI = 0.95-1.78) and prostate cancer mortality (HR = 1.52, 95% CI = 1.12-2.07) comparing BMI >= 35.0 kg/m(2) with 21-22.9 kg/m(2). When considering early adulthood and baseline BMI together, a 27% higher prostate cancer mortality risk (95% CI = 9% to 49%) was observed for men with BMI = 30.0 kg/m(2) at baseline compared with BMI = 110 cm with = 1.00 with = 1.90 m withConclusion: Our findings suggest that height and total and central adiposity in mid-to-later adulthood, but not early adulthood adiposity, are associated with risk of advanced forms of prostate cancer. Thus, maintenance of healthy weight may help prevent advanced prostate cancer.",

keywords = "BMI, CAROTENE, COHORT, MASS INDEX, OBESITY, OVERDIAGNOSIS, PHYSICAL-ACTIVITY, POOLED ANALYSIS, SIZE, SUPPLEMENT USE, WEIGHT CHANGE, body fatness, height, pooled analysis, prostate cancer, waist, ANTHROPOMETRY",

author = "Genkinger, {J. M.} and K. Wu and M. Wang and D. Albanes and A. Black and {van den Brandt}, {P. A.} and Burke, {K. A.} and Cook, {M. B.} and Gapstur, {S. M.} and Giles, {G. G.} and E. Giovannucci and Goodman, {G. G.} and Goodman, {P. J.} and N. Hakansson and Key, {T. J.} and S. Mannisto and {Le Marchand}, L. and Liao, {L. M.} and MacInnis, {R. J.} and Neuhouser, {M. L.} and Platz, {E. A.} and N. Sawada and Schenk, {J. M.} and Stevens, {V. L.} and Travis, {R. C.} and S. Tsugane and K. Visvanathan and Wilkens, {L. R.} and A. Wolk and Smith-Warner, {S. A.}",

note = "Funding Information: The centralization, checking, harmonization, and statistical analyses of the participant level data from each of the cohorts were supported by the National Cancer Institute at the National Institutes of Health grants CA098566 and CA55075 , and by grant 2009/89 from the World Cancer Research Fund International . Funding for the participating cohorts is included in supplementary Table S3 , available at Annals of Oncology online. Publisher Copyright: {\textcopyright} 2019 European Society for Medical Oncology",

year = "2020",

month = jan,

doi = "10.1016/j.annonc.2019.09.007",

language = "English",

volume = "31",

pages = "103--114",

journal = "Annals of Oncology",

issn = "0923-7534",

publisher = "Oxford University Press",

number = "1",

}

Genkinger, JM, Wu, K, Wang, M, Albanes, D, Black, A, van den Brandt, PA, Burke, KA, Cook, MB, Gapstur, SM, Giles, GG, Giovannucci, E, Goodman, GG, Goodman, PJ, Hakansson, N, Key, TJ, Mannisto, S, Le Marchand, L, Liao, LM, MacInnis, RJ, Neuhouser, ML, Platz, EA, Sawada, N, Schenk, JM, Stevens, VL, Travis, RC, Tsugane, S, Visvanathan, K, Wilkens, LR, Wolk, A & Smith-Warner, SA 2020, 'Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer', Annals of Oncology, vol. 31, no. 1, pp. 103-114. https://doi.org/10.1016/j.annonc.2019.09.007

TY - JOUR

T1 - Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer

T2 - risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer

AU - Genkinger, J. M.

AU - Wu, K.

AU - Wang, M.

AU - Albanes, D.

AU - Black, A.

AU - van den Brandt, P. A.

AU - Burke, K. A.

AU - Cook, M. B.

AU - Gapstur, S. M.

AU - Giles, G. G.

AU - Giovannucci, E.

AU - Goodman, G. G.

AU - Goodman, P. J.

AU - Hakansson, N.

AU - Key, T. J.

AU - Mannisto, S.

AU - Le Marchand, L.

AU - Liao, L. M.

AU - MacInnis, R. J.

AU - Neuhouser, M. L.

AU - Platz, E. A.

AU - Sawada, N.

AU - Schenk, J. M.

AU - Stevens, V. L.

AU - Travis, R. C.

AU - Tsugane, S.

AU - Visvanathan, K.

AU - Wilkens, L. R.

AU - Wolk, A.

AU - Smith-Warner, S. A.

N1 - Funding Information: The centralization, checking, harmonization, and statistical analyses of the participant level data from each of the cohorts were supported by the National Cancer Institute at the National Institutes of Health grants CA098566 and CA55075 , and by grant 2009/89 from the World Cancer Research Fund International . Funding for the participating cohorts is included in supplementary Table S3 , available at Annals of Oncology online. Publisher Copyright: © 2019 European Society for Medical Oncology

PY - 2020/1

Y1 - 2020/1

N2 - Background: Advanced prostate cancer etiology is poorly understood. Few studies have examined associations of anthropometric factors (e.g. early adulthood obesity) with advanced prostate cancer risk.Patients and methods: We carried out pooled analyses to examine associations between body fatness, height, and prostate cancer risk. Among 830 772 men, 51 734 incident prostate cancer cases were identified, including 4762 advanced (T4/N1/M1 or prostate cancer deaths) cases, 2915 advanced restricted (same as advanced, but excluding localized cancers that resulted in death) cases, 9489 high-grade cases, and 3027 prostate cancer deaths. Cox proportional hazards models were used to calculate study-specific hazard ratios (HR) and 95% confidence intervals (CI); results were pooled using random effects models.Results: No statistically significant associations were observed for body mass index (BMI) in early adulthood for advanced, advanced restricted, and high-grade prostate cancer, and prostate cancer mortality. Positive associations were shown for BMI at baseline with advanced prostate cancer (HR = 1.30, 95% CI = 0.95-1.78) and prostate cancer mortality (HR = 1.52, 95% CI = 1.12-2.07) comparing BMI >= 35.0 kg/m(2) with 21-22.9 kg/m(2). When considering early adulthood and baseline BMI together, a 27% higher prostate cancer mortality risk (95% CI = 9% to 49%) was observed for men with BMI = 30.0 kg/m(2) at baseline compared with BMI = 110 cm with = 1.00 with = 1.90 m withConclusion: Our findings suggest that height and total and central adiposity in mid-to-later adulthood, but not early adulthood adiposity, are associated with risk of advanced forms of prostate cancer. Thus, maintenance of healthy weight may help prevent advanced prostate cancer.

AB - Background: Advanced prostate cancer etiology is poorly understood. Few studies have examined associations of anthropometric factors (e.g. early adulthood obesity) with advanced prostate cancer risk.Patients and methods: We carried out pooled analyses to examine associations between body fatness, height, and prostate cancer risk. Among 830 772 men, 51 734 incident prostate cancer cases were identified, including 4762 advanced (T4/N1/M1 or prostate cancer deaths) cases, 2915 advanced restricted (same as advanced, but excluding localized cancers that resulted in death) cases, 9489 high-grade cases, and 3027 prostate cancer deaths. Cox proportional hazards models were used to calculate study-specific hazard ratios (HR) and 95% confidence intervals (CI); results were pooled using random effects models.Results: No statistically significant associations were observed for body mass index (BMI) in early adulthood for advanced, advanced restricted, and high-grade prostate cancer, and prostate cancer mortality. Positive associations were shown for BMI at baseline with advanced prostate cancer (HR = 1.30, 95% CI = 0.95-1.78) and prostate cancer mortality (HR = 1.52, 95% CI = 1.12-2.07) comparing BMI >= 35.0 kg/m(2) with 21-22.9 kg/m(2). When considering early adulthood and baseline BMI together, a 27% higher prostate cancer mortality risk (95% CI = 9% to 49%) was observed for men with BMI = 30.0 kg/m(2) at baseline compared with BMI = 110 cm with = 1.00 with = 1.90 m withConclusion: Our findings suggest that height and total and central adiposity in mid-to-later adulthood, but not early adulthood adiposity, are associated with risk of advanced forms of prostate cancer. Thus, maintenance of healthy weight may help prevent advanced prostate cancer.

KW - BMI

KW - CAROTENE

KW - COHORT

KW - MASS INDEX

KW - OBESITY

KW - OVERDIAGNOSIS

KW - PHYSICAL-ACTIVITY

KW - POOLED ANALYSIS

KW - SIZE

KW - SUPPLEMENT USE

KW - WEIGHT CHANGE

KW - body fatness

KW - height

KW - pooled analysis

KW - prostate cancer

KW - waist

KW - ANTHROPOMETRY

U2 - 10.1016/j.annonc.2019.09.007

DO - 10.1016/j.annonc.2019.09.007

M3 - Article

C2 - 31912782

SN - 0923-7534

VL - 31

SP - 103

EP - 114

JO - Annals of Oncology

JF - Annals of Oncology

IS - 1

ER -

Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer

Abstract

Keywords

Access to Document

Research output

Corrigendum to ‘Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer’ [Annals of Oncology Volume 31, Issue 1, January 2020, Pages 103-114]

Cite this