TY - JOUR
T1 - Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment
AU - Clerx, Lies
AU - van Rossum, Ineke A.
AU - Burns, Leah
AU - Knol, Dirk L.
AU - Scheltens, Philip
AU - Verhey, Frans
AU - Aalten, Pauline
AU - Lapuerta, Pablo
AU - van de Pol, Laura
AU - van Schijndel, Ronald
AU - de Jong, Remko
AU - Barkhof, Frederik
AU - Wolz, Robin
AU - Rueckert, Daniel
AU - Bocchetta, Martina
AU - Tsolaki, Magdalini
AU - Nobili, Flavio
AU - Wahlund, Lars-Olaf
AU - Minthon, Lennart
AU - Froelich, Lutz
AU - Hampel, Harald
AU - Soininen, Hilkka
AU - Visser, Pieter Jelle
PY - 2013/8
Y1 - 2013/8
N2 - Our aim was to compare the predictive accuracy of 4 different medial temporal lobe measurements for Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI). Manual hippocampal measurement, automated atlas-based hippocampal measurement, a visual rating scale (MTA-score), and lateral ventricle measurement were compared. Predictive accuracy for AD 2 years after baseline was assessed by receiver operating characteristics analyses with area under the curve as outcome. Annual cognitive decline was assessed by slope analyses up to 5 years after baseline. Correlations with biomarkers in cerebrospinal fluid (CSF) were investigated. Subjects with MCI were selected from the Development of Screening Guidelines and Clinical Criteria for Predementia AD (DESCRIPA) multicenter study (n = 156) and the single-center VU medical center (n = 172). At follow-up, area under the curve was highest for automated atlas-based hippocampal measurement (0.71) and manual hippocampal measurement (0.71), and lower for MTA-score (0.65) and lateral ventricle (0.60). Slope analysis yielded similar results. Hippocampal measurements correlated with CSF total tau and phosphorylated tau, not with beta-amyloid 1-42. MTA-score and lateral ventricle volume correlated with CSF beta-amyloid 1-42. We can conclude that volumetric hippocampal measurements are the best predictors of AD conversion in subjects with MCI.
AB - Our aim was to compare the predictive accuracy of 4 different medial temporal lobe measurements for Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI). Manual hippocampal measurement, automated atlas-based hippocampal measurement, a visual rating scale (MTA-score), and lateral ventricle measurement were compared. Predictive accuracy for AD 2 years after baseline was assessed by receiver operating characteristics analyses with area under the curve as outcome. Annual cognitive decline was assessed by slope analyses up to 5 years after baseline. Correlations with biomarkers in cerebrospinal fluid (CSF) were investigated. Subjects with MCI were selected from the Development of Screening Guidelines and Clinical Criteria for Predementia AD (DESCRIPA) multicenter study (n = 156) and the single-center VU medical center (n = 172). At follow-up, area under the curve was highest for automated atlas-based hippocampal measurement (0.71) and manual hippocampal measurement (0.71), and lower for MTA-score (0.65) and lateral ventricle (0.60). Slope analysis yielded similar results. Hippocampal measurements correlated with CSF total tau and phosphorylated tau, not with beta-amyloid 1-42. MTA-score and lateral ventricle volume correlated with CSF beta-amyloid 1-42. We can conclude that volumetric hippocampal measurements are the best predictors of AD conversion in subjects with MCI.
KW - Alzheimer's disease
KW - Mild cognitive impairment
KW - Dementia
KW - Magnetic resonance imaging
KW - Medial temporal lobe atrophy
KW - Cerebrospinal fluid (CSF)
KW - A beta 1-42
KW - Tau
U2 - 10.1016/j.neurobiolaging.2013.02.002
DO - 10.1016/j.neurobiolaging.2013.02.002
M3 - Article
C2 - 23540941
SN - 0197-4580
VL - 34
SP - 2003
EP - 2013
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 8
ER -