TY - JOUR
T1 - Measurement properties of the Timed Up & Go test in patients with COPD
AU - Barreto de Mesquita, Rafael
AU - Wilke, Sarah
AU - Smid, Dionne E.
AU - Janssen, Daisy J. A.
AU - Franssen, Frits M. E.
AU - Probst, Vanessa S.
AU - Wouters, Emiel F. M.
AU - Muris, Johannes
AU - Pitta, Fabio
AU - Spruit, Martijn A.
PY - 2016/11
Y1 - 2016/11
N2 - We aimed to investigate the construct validity of the Timed Up & Go (TUG) test in chronic obstructive pulmonary disease (COPD), to identify characteristics related to an abnormal TUG time and to examine the responsiveness of the TUG to pulmonary rehabilitation (PR). TUG time was assessed before and after comprehensive PR in 500 COPD patients, and compared cross-sectionally in 100 non-COPD subjects. Physical health outcomes, mental health outcomes, symptom-related outcomes and multidimensional indices were assessed in COPD patients only. Good convergent and discriminant validity was demonstrated by fair-to-moderate correlation with physical health outcomes, symptom-related outcomes and multidimensional indices (r(s) = 0.18-0.70) and by little correlation with mental health outcomes (r(s) = 0.21-0.26). COPD patients had a worse TUG time than non-COPD subjects, demonstrating known-groups validity. A TUG time of 11.2 seconds had good sensitivity (0.75) and specificity (0.83) for identifying patients with a baseline 6-minute walk distance <350 m. TUG time improved after PR (p < 0.0001) and a change of 0.9-1.4 seconds was identified as clinically important. The TUG is valid and responsive in COPD. An abnormal result is indicative of poor health outcomes. This simple test provides valuable information and can be adopted in clinical and research settings
AB - We aimed to investigate the construct validity of the Timed Up & Go (TUG) test in chronic obstructive pulmonary disease (COPD), to identify characteristics related to an abnormal TUG time and to examine the responsiveness of the TUG to pulmonary rehabilitation (PR). TUG time was assessed before and after comprehensive PR in 500 COPD patients, and compared cross-sectionally in 100 non-COPD subjects. Physical health outcomes, mental health outcomes, symptom-related outcomes and multidimensional indices were assessed in COPD patients only. Good convergent and discriminant validity was demonstrated by fair-to-moderate correlation with physical health outcomes, symptom-related outcomes and multidimensional indices (r(s) = 0.18-0.70) and by little correlation with mental health outcomes (r(s) = 0.21-0.26). COPD patients had a worse TUG time than non-COPD subjects, demonstrating known-groups validity. A TUG time of 11.2 seconds had good sensitivity (0.75) and specificity (0.83) for identifying patients with a baseline 6-minute walk distance <350 m. TUG time improved after PR (p < 0.0001) and a change of 0.9-1.4 seconds was identified as clinically important. The TUG is valid and responsive in COPD. An abnormal result is indicative of poor health outcomes. This simple test provides valuable information and can be adopted in clinical and research settings
KW - Chronic obstructive pulmonary disease
KW - outcome assessment (healthcare)
KW - rehabilitation
U2 - 10.1177/1479972316647178
DO - 10.1177/1479972316647178
M3 - Article
C2 - 27165963
SN - 1479-9723
VL - 13
SP - 344
EP - 352
JO - Chronic respiratory disease
JF - Chronic respiratory disease
IS - 4
ER -