Measurement of human abdominal and femoral intravascular adipose tissue blood flow using percutaneous Doppler ultrasound

I.G. Lempesis*, G.H. Goossens, K.N. Manolopoulos

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Adipose tissue blood flow (ATBF) is an important determinant of adipose tissue (AT) function. (133)Xenon wash-out technique is considered the gold-standard for human ATBF measurements. However, decreasing (133)Xenon clinical use and costly production and preservation, make alternative (non-invasive) methods necessary. Here, we explored percutaneous Doppler ultrasound as a proxy method to quantify intravascular subcutaneous abdominal and femoral ATBF in humans (n= 17). Both fasting ATBF and the postprandial increase in ATBF were significantly higher in abdominal compared to femoral AT. Although anatomical variations in vein location and depot thickness may impact feasibility, we demonstrate that Doppler ultrasound detects the expected depot-differences and postprandial increase in ATBF in healthy individuals. This method warrants further investigation in other populations and metabolic conditions.
Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalAdipocyte
Volume10
Issue number1
DOIs
Publication statusPublished - 1 Jan 2021

Keywords

  • adipose tissue
  • blood flow
  • doppler ultrasound
  • fat depots
  • human physiology
  • Adipose tissue
  • Doppler ultrasound

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