Measurement of dabigatran in standardly used clinical assays, whole blood viscoelastic coagulation, and thrombin generation assays

Joanne van Ryn, Oliver Grottke, Henri Spronk

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Dabigatran, a direct thrombin inhibitor, is increasingly used clinically as one of the new oral anticoagulants. This review summarizes the assays available to measure its activity and includes the relative sensitivity of the different assays for this agent. In addition to plasma-based clotting tests, assays commonly used in surgical/emergency settings, such as activated clotting time and thromboelastometry/thromboelastography, are reviewed. In addition, the thrombin generation assay is discussed as an important method to determine the potential risk of thrombosis or bleeding and its relevance to the measurement of direct thrombin inhibitors.

Original languageEnglish
Pages (from-to)479-501
Number of pages23
JournalClinics in Laboratory Medicine
Volume34
Issue number3
DOIs
Publication statusPublished - Sep 2014

Keywords

  • Administration, Oral
  • Animals
  • Antithrombins/administration & dosage
  • Benzimidazoles/administration & dosage
  • Blood Coagulation/drug effects
  • Blood Coagulation Tests
  • Dabigatran
  • Drug Monitoring/methods
  • Humans
  • Precision Medicine
  • beta-Alanine/administration & dosage

Cite this