Maternal Transmission of Symptomatic Clostridioides difficile Infection to Two Premature Neonates

Dina Seljogi; Arthur L.E.M. Vanhove; Judith L. Vogelzang; Stefan A. Boers; Joffrey Van Prehn; Marc A. Benninga; Ed Kuijper; E. K.L. Berssenbrugge; S. A. Boers; C. Harmanus; M. E.M. Kraakman; Ed Kuijper; Joffrey Van Prehn; I. M.J.G. Sanders; W. K. Smits; E. Wessels; S. De Greeff; D. W. Notermans; K. E.W. Vendrik; S. B. Debast; K. I. Wold; W. Van Den Bijllaardt; H. A. Van Dessel; National Expertise Center for Clostridioides difficile Infections

doi:10.1097/INF.0000000000004852

Maternal Transmission of Symptomatic Clostridioides difficile Infection to Two Premature Neonates

Dina Seljogi^*, Arthur L.E.M. Vanhove, Judith L. Vogelzang, Stefan A. Boers, Joffrey Van Prehn, Marc A. Benninga, Ed Kuijper, E. K.L. Berssenbrugge, S. A. Boers, C. Harmanus, M. E.M. Kraakman, Ed Kuijper, Joffrey Van Prehn, I. M.J.G. Sanders, W. K. Smits, E. Wessels, S. De Greeff, D. W. Notermans, K. E.W. Vendrik, S. B. DebastK. I. Wold, W. Van Den Bijllaardt, H. A. Van Dessel, National Expertise Center for Clostridioides difficile Infections

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Clostridioides difficile infections (CDI) in neonates are challenging to diagnose due to high asymptomatic gut colonization rates with C. difficile in newborns and the difficulty of differentiating colonization and infection. Objective: We describe a case of a severe CDI with a complicated course in a 48-year-old mother who had prior hospitalization and antibiotic treatment. She gave birth to a triplet at a gestational age of 31 weeks and transmitted toxin-producing C. difficile belonging to polymerase chain reaction ribotype 002 onto 3 newborns of which 2 developed diarrhea which responded well to anti-CDI treatment. Conclusion: Testing for CDI in neonates should be considered if the mother developed CDI during the peripartum period.

Original language	English
Number of pages	3
Journal	Pediatric Infectious Disease Journal
DOIs	https://doi.org/10.1097/INF.0000000000004852
Publication status	E-pub ahead of print - 1 Jan 2025

Keywords

Clostridioides difficile infection
maternal transmission
whole genome sequencing

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10.1097/INF.0000000000004852

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Seljogi, D., Vanhove, A. L. E. M., Vogelzang, J. L., Boers, S. A., Van Prehn, J., Benninga, M. A., Kuijper, E., Berssenbrugge, E. K. L., Boers, S. A., Harmanus, C., Kraakman, M. E. M., Kuijper, E., Van Prehn, J., Sanders, I. M. J. G., Smits, W. K., Wessels, E., De Greeff, S., Notermans, D. W., Vendrik, K. E. W., ... National Expertise Center for Clostridioides difficile Infections (2025). Maternal Transmission of Symptomatic Clostridioides difficile Infection to Two Premature Neonates. Pediatric Infectious Disease Journal. Advance online publication. https://doi.org/10.1097/INF.0000000000004852

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title = "Maternal Transmission of Symptomatic Clostridioides difficile Infection to Two Premature Neonates",

abstract = "Background: Clostridioides difficile infections (CDI) in neonates are challenging to diagnose due to high asymptomatic gut colonization rates with C. difficile in newborns and the difficulty of differentiating colonization and infection. Objective: We describe a case of a severe CDI with a complicated course in a 48-year-old mother who had prior hospitalization and antibiotic treatment. She gave birth to a triplet at a gestational age of 31 weeks and transmitted toxin-producing C. difficile belonging to polymerase chain reaction ribotype 002 onto 3 newborns of which 2 developed diarrhea which responded well to anti-CDI treatment. Conclusion: Testing for CDI in neonates should be considered if the mother developed CDI during the peripartum period.",

keywords = "Clostridioides difficile infection, maternal transmission, whole genome sequencing",

author = "Dina Seljogi and Vanhove, \{Arthur L.E.M.\} and Vogelzang, \{Judith L.\} and Boers, \{Stefan A.\} and \{Van Prehn\}, Joffrey and Benninga, \{Marc A.\} and Ed Kuijper and Berssenbrugge, \{E. K.L.\} and Boers, \{S. A.\} and C. Harmanus and Kraakman, \{M. E.M.\} and Ed Kuijper and \{Van Prehn\}, Joffrey and Sanders, \{I. M.J.G.\} and Smits, \{W. K.\} and E. Wessels and \{De Greeff\}, S. and Notermans, \{D. W.\} and Vendrik, \{K. E.W.\} and Debast, \{S. B.\} and Wold, \{K. I.\} and \{Van Den Bijllaardt\}, W. and \{Van Dessel\}, \{H. A.\} and \{National Expertise Center for Clostridioides difficile Infections\}",

year = "2025",

month = jan,

day = "1",

doi = "10.1097/INF.0000000000004852",

language = "English",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams \& Wilkins",

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Seljogi, D, Vanhove, ALEM, Vogelzang, JL, Boers, SA, Van Prehn, J, Benninga, MA, Kuijper, E, Berssenbrugge, EKL, Boers, SA, Harmanus, C, Kraakman, MEM, Kuijper, E, Van Prehn, J, Sanders, IMJG, Smits, WK, Wessels, E, De Greeff, S, Notermans, DW, Vendrik, KEW, Debast, SB, Wold, KI, Van Den Bijllaardt, W, Van Dessel, HA & National Expertise Center for Clostridioides difficile Infections 2025, 'Maternal Transmission of Symptomatic Clostridioides difficile Infection to Two Premature Neonates', Pediatric Infectious Disease Journal. https://doi.org/10.1097/INF.0000000000004852

TY - JOUR

T1 - Maternal Transmission of Symptomatic Clostridioides difficile Infection to Two Premature Neonates

AU - Seljogi, Dina

AU - Vanhove, Arthur L.E.M.

AU - Vogelzang, Judith L.

AU - Boers, Stefan A.

AU - Van Prehn, Joffrey

AU - Benninga, Marc A.

AU - Kuijper, Ed

AU - Berssenbrugge, E. K.L.

AU - Boers, S. A.

AU - Harmanus, C.

AU - Kraakman, M. E.M.

AU - Kuijper, Ed

AU - Van Prehn, Joffrey

AU - Sanders, I. M.J.G.

AU - Smits, W. K.

AU - Wessels, E.

AU - De Greeff, S.

AU - Notermans, D. W.

AU - Vendrik, K. E.W.

AU - Debast, S. B.

AU - Wold, K. I.

AU - Van Den Bijllaardt, W.

AU - Van Dessel, H. A.

AU - National Expertise Center for Clostridioides difficile Infections

PY - 2025/1/1

Y1 - 2025/1/1

N2 - Background: Clostridioides difficile infections (CDI) in neonates are challenging to diagnose due to high asymptomatic gut colonization rates with C. difficile in newborns and the difficulty of differentiating colonization and infection. Objective: We describe a case of a severe CDI with a complicated course in a 48-year-old mother who had prior hospitalization and antibiotic treatment. She gave birth to a triplet at a gestational age of 31 weeks and transmitted toxin-producing C. difficile belonging to polymerase chain reaction ribotype 002 onto 3 newborns of which 2 developed diarrhea which responded well to anti-CDI treatment. Conclusion: Testing for CDI in neonates should be considered if the mother developed CDI during the peripartum period.

AB - Background: Clostridioides difficile infections (CDI) in neonates are challenging to diagnose due to high asymptomatic gut colonization rates with C. difficile in newborns and the difficulty of differentiating colonization and infection. Objective: We describe a case of a severe CDI with a complicated course in a 48-year-old mother who had prior hospitalization and antibiotic treatment. She gave birth to a triplet at a gestational age of 31 weeks and transmitted toxin-producing C. difficile belonging to polymerase chain reaction ribotype 002 onto 3 newborns of which 2 developed diarrhea which responded well to anti-CDI treatment. Conclusion: Testing for CDI in neonates should be considered if the mother developed CDI during the peripartum period.

KW - Clostridioides difficile infection

KW - maternal transmission

KW - whole genome sequencing

U2 - 10.1097/INF.0000000000004852

DO - 10.1097/INF.0000000000004852

M3 - Article

SN - 0891-3668

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

ER -

Maternal Transmission of Symptomatic Clostridioides difficile Infection to Two Premature Neonates

Abstract

Keywords

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