Maternal sepsis in the era of genomic medicine

C. Kouskouti*, N. Evangelatos, A. Brand, F. Kainer

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Web of Science)

Abstract

Purpose Maternal sepsis remains one of the leading causes of direct and indirect maternal mortality both in high- and low-income environments. In the last two decades, systems biology approaches, based on '-omics' technologies, have started revolutionizing the diagnosis and management of the septic syndrome. The scope of this narrative review is to present an overview of the basic '-omics' technologies, exemplified by cases relevant to maternal sepsis. Methods Narrative review of the new '-omics' technologies based on a detailed review of the literature. Results After presenting the main 'omics' technologies, we discuss their limitations and the need for integrated approaches that encompass research efforts across multiple '-omics' layers in the '-omics' cascade between the genome and the phenome. Conclusions Systems biology approaches are revolutionizing the research landscape in maternal sepsis. There is a need for increased awareness, from the side of health practitioners, as a requirement for the effective implementation of the new technologies in the research and clinical practice in maternal sepsis.
Original languageEnglish
Pages (from-to)49-60
Number of pages12
JournalArchives of Gynecology and Obstetrics
Volume297
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Maternal sepsis
  • Genomic medicine
  • Systems biology
  • Integrated '-omics'
  • INTENSIVE-CARE-UNIT
  • SEPTIC SHOCK
  • WIDE ASSOCIATION
  • STREPTOCOCCUS-PYOGENES
  • STAPHYLOCOCCUS-AUREUS
  • PERSONALIZED MEDICINE
  • HEALTH
  • PREGNANCY
  • EXPRESSION
  • PROTEOMICS

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