TY - JOUR
T1 - Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome
AU - Sinha, Trishla
AU - Prins, Jelmer R.
AU - Fernandez-Pato, Asier
AU - Kruk, Marloes
AU - Dierikx, Thomas
AU - de Meij, Tim
AU - de Boer, Marjon
AU - de Boer, Jan Freark
AU - Scherjon, Sicco
AU - Kurilshikov, Alexander
AU - Zhernakova, Alexandra
PY - 2024/8/14
Y1 - 2024/8/14
N2 - Pregnant women undergoing a cesarean section (CS) typically receive antibiotics prior to skin incision to prevent infections. To investigate if the timing of antibiotics influences the infant gut microbiome, we conducted a randomized controlled trial (NCT06030713) in women delivering via a scheduled CS who received antibiotics either before skin incision or after umbilical cord clamping. We performed a longitudinal analysis on 172 samples from 28 infants at 8 post-birth time points and a cross-sectional analysis at 1 month in 79 infants from 3 cohorts. Although no significant associations with bacterial composition, metabolic pathways, short- chain fatty acids, and bile acids were found, we observed subtle differences between the groups at the bacterial strain level and in the load of antibiotic resistance genes. Rather, feeding mode was a predominant and defining factor impacting infant microbial composition. In conclusion, antibiotic administration during CS has only limited effects on the early-life gut microbiome.
AB - Pregnant women undergoing a cesarean section (CS) typically receive antibiotics prior to skin incision to prevent infections. To investigate if the timing of antibiotics influences the infant gut microbiome, we conducted a randomized controlled trial (NCT06030713) in women delivering via a scheduled CS who received antibiotics either before skin incision or after umbilical cord clamping. We performed a longitudinal analysis on 172 samples from 28 infants at 8 post-birth time points and a cross-sectional analysis at 1 month in 79 infants from 3 cohorts. Although no significant associations with bacterial composition, metabolic pathways, short- chain fatty acids, and bile acids were found, we observed subtle differences between the groups at the bacterial strain level and in the load of antibiotic resistance genes. Rather, feeding mode was a predominant and defining factor impacting infant microbial composition. In conclusion, antibiotic administration during CS has only limited effects on the early-life gut microbiome.
U2 - 10.1016/j.chom.2024.07.010
DO - 10.1016/j.chom.2024.07.010
M3 - Article
SN - 1931-3128
VL - 32
SP - 1444-1454.e6
JO - Cell Host Microbe
JF - Cell Host Microbe
IS - 8
ER -