Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas

H C. Hafkamp, J.J. Manni, A. Haesvoets, A.C. Voogd, M. Schepers, F.J. Bot, A.H.N. Hopman, F.C.S. Ramaekers, E.J.M. Speel

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Abstract

Oncogenic human papillomavirus (HPV) is a causative agent in a subgroup of head and neck carcinomas, particularly tonsillar squamous cell carcinomas (TSCC). This study was undertaken because controversial data exist on the physical status of HPV-DNA and the use of p16(INK4A) overexpression as surrogate HPV marker, and to examine the impact of HPV and tobacco consumption on the clinical course of TSCC. Tissue sections of 81 TSCC were analyzed by HPV 16-specific fluorescence in situ hybridization (FISH) and p(16INK4A)-specific immunohistochemistry. Results were correlated with clinical and demographic data. HPV 16 integration was detected by FISH as punctate signals in 33 out of 81 (41%) TSCC, 32 of which showed p16(INK4A) accumulation. Only 5 out of 48 HPV-negative tumors showed p16(INK4A) immunostaining (p
Original languageEnglish
Pages (from-to)2656-2664
JournalInternational Journal of Cancer
Volume122
Issue number12
DOIs
Publication statusPublished - 1 Jan 2008

Cite this

Hafkamp, H. C., Manni, J. J., Haesvoets, A., Voogd, A. C., Schepers, M., Bot, F. J., Hopman, A. H. N., Ramaekers, F. C. S., & Speel, E. J. M. (2008). Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas. International Journal of Cancer, 122(12), 2656-2664. https://doi.org/10.1002/ijc.23458