Managing biological data in pathways and networks

Research output: ThesisDoctoral ThesisInternal

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Abstract

Networks of Life
In the many cells in our body genes, proteins and metabolites work together. As soon as something in this complex network goes wrong, disease may occur. In a flourishing new research field called Systems Biology, we try to better understand how cells work in health and disease. In this thesis, new tools are presented to organize, visualize and analyse how proteins are connected with each other and other functional elements and how they affect the function and behaviour of the cells. By analysing nutrition and obesity studies, it is demonstrated how these new tools can be used to better understand how the processes are connected and how they can be influenced by different drugs and nutrients.This gives pointers for better combined therapies and healthier diets.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Evelo, Chris, Supervisor
  • Steinbusch - Coort, Susan, Supervisor
Award date22 Jan 2015
Place of Publication's-Hertogenbosch
Publisher
Print ISBNs9789462950443
Publication statusPublished - 1 Jan 2015

Keywords

  • Systems Biology
  • networks
  • nutrition

Cite this

Kutmon, M. (2015). Managing biological data in pathways and networks. 's-Hertogenbosch: Uitgeverij BOXPress.
Kutmon, M.. / Managing biological data in pathways and networks. 's-Hertogenbosch : Uitgeverij BOXPress, 2015. 142 p.
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Kutmon, M 2015, 'Managing biological data in pathways and networks', Doctor of Philosophy, Maastricht University, 's-Hertogenbosch.

Managing biological data in pathways and networks. / Kutmon, M.

's-Hertogenbosch : Uitgeverij BOXPress, 2015. 142 p.

Research output: ThesisDoctoral ThesisInternal

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N2 - Networks of LifeIn the many cells in our body genes, proteins and metabolites work together. As soon as something in this complex network goes wrong, disease may occur. In a flourishing new research field called Systems Biology, we try to better understand how cells work in health and disease. In this thesis, new tools are presented to organize, visualize and analyse how proteins are connected with each other and other functional elements and how they affect the function and behaviour of the cells. By analysing nutrition and obesity studies, it is demonstrated how these new tools can be used to better understand how the processes are connected and how they can be influenced by different drugs and nutrients.This gives pointers for better combined therapies and healthier diets.

AB - Networks of LifeIn the many cells in our body genes, proteins and metabolites work together. As soon as something in this complex network goes wrong, disease may occur. In a flourishing new research field called Systems Biology, we try to better understand how cells work in health and disease. In this thesis, new tools are presented to organize, visualize and analyse how proteins are connected with each other and other functional elements and how they affect the function and behaviour of the cells. By analysing nutrition and obesity studies, it is demonstrated how these new tools can be used to better understand how the processes are connected and how they can be influenced by different drugs and nutrients.This gives pointers for better combined therapies and healthier diets.

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KW - networks

KW - nutrition

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CY - 's-Hertogenbosch

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Kutmon M. Managing biological data in pathways and networks. 's-Hertogenbosch: Uitgeverij BOXPress, 2015. 142 p.