Management of encapsulating peritoneal sclerosis: a guideline on optimal and uniform treatment

S. M. Habib, M. G. H. Betjes*, M. W. J. A. Fieren, Elisabeth W. Boeschoten, A. C. Abrahams, W.H. Boer, Dirk G. Struijk, W. Ruger, Christina Krikke, Ralf Westerhuis, R. G. L. de Sevaux, F. M. van der Sande, A. Gaasbeek, M. R. Korte

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

57 Citations (Web of Science)

Abstract

Encapsulating peritoneal sclerosis (EPS) represents a rare complication of long-term peritoneal dialysis (PD). It is characterised by diffuse peritoneal membrane fibrosis, progressive intestinal encapsulation and the clinical spectrum of intestinal obstruction. The pathogenesis is as yet not well understood but includes inflammation, angiogenesis and fibrosis. The current diagnosis of EPS lacks specificity and relies on clinical, radiographic or macroscopic evaluation. There is no general agreement on managing EPS although accumulating clinical data suggest drug treatment (steroids, tamoxifen), surgery (enterolysis) or a combination of both. Here, we provide a short overview on the current knowledge of EPS, with a focus on treatment. Moreover, we present a diagnostic and a therapeutic algorithm for EPS based on the best available published data and our combined experience.
Original languageEnglish
Pages (from-to)500-507
JournalNetherlands Journal of Medicine
Volume69
Issue number11
Publication statusPublished - 2011

Keywords

  • Encapsulating peritoneal sclerosis
  • enterolysis
  • immune suppressive
  • management algorithm
  • peritoneal dialysis

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