Management of anaphylaxis due to COVID-19 vaccines in the elderly

J. Bousquet; I. Agache; H. Blain; M. Jutel; M.T. Ventura; M. Worm; S. Del Giacco; A. Benetos; B.M. Bilo; W. Czarlewski; A.H.A. Latiff; M. Al-Ahmad; E. Angier; I. Annesi-Maesano; M. Atanaskovic-Markovic; C. Bachert; A. Barbaud; A. Bedbrook; K.S. Bennoor; E.C. Berghea; C. Bindslev-Jensen; S. Bonini; S. Bosnic-Anticevich; K. Brockow; L. Brussino; P. Camargos; G.W. Canonica; V. Cardona; P. Carreiro-Martins; A. Carriazo; T. Casale; J.C. Caubet; L. Cecchi; A. Cherubini; G. Christoff; D.R.K. Chu; A.A. Cruz; D. Dokic; Y. El-Gamal; M. Ebisawa; B. Eberlein; J. Farrell; M. Fernandez-Rivas; W.J. Fokkens; J.A. Fonseca; Y.D. Gao; G. Gavazzi; R. Gawlik; A. Gelincik; B. Gemicioglu; Jos Schols

doi:10.1111/all.14838

Management of anaphylaxis due to COVID-19 vaccines in the elderly

J. Bousquet^*, I. Agache, H. Blain, M. Jutel, M.T. Ventura, M. Worm, S. Del Giacco, A. Benetos, B.M. Bilo, W. Czarlewski, A.H.A. Latiff, M. Al-Ahmad, E. Angier, I. Annesi-Maesano, M. Atanaskovic-Markovic, C. Bachert, A. Barbaud, A. Bedbrook, K.S. Bennoor, E.C. BergheaC. Bindslev-Jensen, S. Bonini, S. Bosnic-Anticevich, K. Brockow, L. Brussino, P. Camargos, G.W. Canonica, V. Cardona, P. Carreiro-Martins, A. Carriazo, T. Casale, J.C. Caubet, L. Cecchi, A. Cherubini, G. Christoff, D.R.K. Chu, A.A. Cruz, D. Dokic, Y. El-Gamal, M. Ebisawa, B. Eberlein, J. Farrell, M. Fernandez-Rivas, W.J. Fokkens, J.A. Fonseca, Y.D. Gao, G. Gavazzi, R. Gawlik, A. Gelincik, B. Gemicioglu, Jos Schols

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Web of Science)

Abstract

Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.

Original language	English
Pages (from-to)	2952-2964
Number of pages	13
Journal	Allergy
Volume	76
Issue number	10
DOIs	https://doi.org/10.1111/all.14838
Publication status	Published - 1 Oct 2021

Keywords

adrenaline
anaphylaxis
COVID-19 vaccines
older (adults
people)
GUIDELINES
EPINEPHRINE
RISK

Access to Document

10.1111/all.14838

Cite this

Bousquet, J., Agache, I., Blain, H., Jutel, M., Ventura, M. T., Worm, M., Del Giacco, S., Benetos, A., Bilo, B. M., Czarlewski, W., Latiff, A. H. A., Al-Ahmad, M., Angier, E., Annesi-Maesano, I., Atanaskovic-Markovic, M., Bachert, C., Barbaud, A., Bedbrook, A., Bennoor, K. S., ... Schols, J. (2021). Management of anaphylaxis due to COVID-19 vaccines in the elderly. Allergy, 76(10), 2952-2964. https://doi.org/10.1111/all.14838

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title = "Management of anaphylaxis due to COVID-19 vaccines in the elderly",

abstract = "Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.",

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author = "J. Bousquet and I. Agache and H. Blain and M. Jutel and M.T. Ventura and M. Worm and {Del Giacco}, S. and A. Benetos and B.M. Bilo and W. Czarlewski and A.H.A. Latiff and M. Al-Ahmad and E. Angier and I. Annesi-Maesano and M. Atanaskovic-Markovic and C. Bachert and A. Barbaud and A. Bedbrook and K.S. Bennoor and E.C. Berghea and C. Bindslev-Jensen and S. Bonini and S. Bosnic-Anticevich and K. Brockow and L. Brussino and P. Camargos and G.W. Canonica and V. Cardona and P. Carreiro-Martins and A. Carriazo and T. Casale and J.C. Caubet and L. Cecchi and A. Cherubini and G. Christoff and D.R.K. Chu and A.A. Cruz and D. Dokic and Y. El-Gamal and M. Ebisawa and B. Eberlein and J. Farrell and M. Fernandez-Rivas and W.J. Fokkens and J.A. Fonseca and Y.D. Gao and G. Gavazzi and R. Gawlik and A. Gelincik and B. Gemicioglu and Jos Schols",

year = "2021",

month = oct,

day = "1",

doi = "10.1111/all.14838",

language = "English",

volume = "76",

pages = "2952--2964",

journal = "Allergy",

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Bousquet, J, Agache, I, Blain, H, Jutel, M, Ventura, MT, Worm, M, Del Giacco, S, Benetos, A, Bilo, BM, Czarlewski, W, Latiff, AHA, Al-Ahmad, M, Angier, E, Annesi-Maesano, I, Atanaskovic-Markovic, M, Bachert, C, Barbaud, A, Bedbrook, A, Bennoor, KS, Berghea, EC, Bindslev-Jensen, C, Bonini, S, Bosnic-Anticevich, S, Brockow, K, Brussino, L, Camargos, P, Canonica, GW, Cardona, V, Carreiro-Martins, P, Carriazo, A, Casale, T, Caubet, JC, Cecchi, L, Cherubini, A, Christoff, G, Chu, DRK, Cruz, AA, Dokic, D, El-Gamal, Y, Ebisawa, M, Eberlein, B, Farrell, J, Fernandez-Rivas, M, Fokkens, WJ, Fonseca, JA, Gao, YD, Gavazzi, G, Gawlik, R, Gelincik, A, Gemicioglu, B & Schols, J 2021, 'Management of anaphylaxis due to COVID-19 vaccines in the elderly', Allergy, vol. 76, no. 10, pp. 2952-2964. https://doi.org/10.1111/all.14838

TY - JOUR

T1 - Management of anaphylaxis due to COVID-19 vaccines in the elderly

AU - Bousquet, J.

AU - Agache, I.

AU - Blain, H.

AU - Jutel, M.

AU - Ventura, M.T.

AU - Worm, M.

AU - Del Giacco, S.

AU - Benetos, A.

AU - Bilo, B.M.

AU - Czarlewski, W.

AU - Latiff, A.H.A.

AU - Al-Ahmad, M.

AU - Angier, E.

AU - Annesi-Maesano, I.

AU - Atanaskovic-Markovic, M.

AU - Bachert, C.

AU - Barbaud, A.

AU - Bedbrook, A.

AU - Bennoor, K.S.

AU - Berghea, E.C.

AU - Bindslev-Jensen, C.

AU - Bonini, S.

AU - Bosnic-Anticevich, S.

AU - Brockow, K.

AU - Brussino, L.

AU - Camargos, P.

AU - Canonica, G.W.

AU - Cardona, V.

AU - Carreiro-Martins, P.

AU - Carriazo, A.

AU - Casale, T.

AU - Caubet, J.C.

AU - Cecchi, L.

AU - Cherubini, A.

AU - Christoff, G.

AU - Chu, D.R.K.

AU - Cruz, A.A.

AU - Dokic, D.

AU - El-Gamal, Y.

AU - Ebisawa, M.

AU - Eberlein, B.

AU - Farrell, J.

AU - Fernandez-Rivas, M.

AU - Fokkens, W.J.

AU - Fonseca, J.A.

AU - Gao, Y.D.

AU - Gavazzi, G.

AU - Gawlik, R.

AU - Gelincik, A.

AU - Gemicioglu, B.

AU - Schols, Jos

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.

AB - Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.

KW - adrenaline

KW - anaphylaxis

KW - COVID-19 vaccines

KW - older (adults

KW - people)

KW - GUIDELINES

KW - EPINEPHRINE

KW - RISK

U2 - 10.1111/all.14838

DO - 10.1111/all.14838

M3 - Article

C2 - 33811358

VL - 76

SP - 2952

EP - 2964

JO - Allergy

JF - Allergy

SN - 0105-4538

IS - 10

ER -