Malnutrition and Fracture Healing: Are Specific Deficiencies in Amino Acids Important in Nonunion Development?

Dennis M. Meesters*, Karolina A. P. Wijnands, Peter R. G. Brink, Martijn Poeze

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Citations (Web of Science)

Abstract

With the increasing incidence of fractures now, and in the future, the absolute number of bone-healing complications such as nonunion development will also increase. Next to fracture-dependent factors such as large bone loss volumes and inadequate stabilization, the nutritional state of these patients is a major influential factor for the fracture repair process. In this review, we will focus on the influence of protein/amino acid malnutrition and its influence on fracture healing. Mainly, the arginine-citrulline-nitric oxide metabolism is of importance since it can affect fracture healing via several precursors of collagen formation, and through nitric oxide synthases it has influences on the bio-molecular inflammatory responses and the local capillary growth and circulation.

Original languageEnglish
Article number1597
Number of pages12
JournalNutrients
Volume10
Issue number11
DOIs
Publication statusPublished - Nov 2018

Keywords

  • fracture healing
  • nonunion
  • arginine
  • citrulline
  • nitric oxide
  • nitric oxide synthase
  • NITRIC-OXIDE SYNTHASE
  • BONE MORPHOGENETIC PROTEINS
  • L-ARGININE
  • RISK-FACTORS
  • COLLAGEN-SYNTHESIS
  • ELDERLY-PATIENTS
  • EXPRESSION
  • GROWTH
  • CLASSIFICATION
  • EPIDEMIOLOGY

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