Abstract
With the increasing incidence of fractures now, and in the future, the absolute number of bone-healing complications such as nonunion development will also increase. Next to fracture-dependent factors such as large bone loss volumes and inadequate stabilization, the nutritional state of these patients is a major influential factor for the fracture repair process. In this review, we will focus on the influence of protein/amino acid malnutrition and its influence on fracture healing. Mainly, the arginine-citrulline-nitric oxide metabolism is of importance since it can affect fracture healing via several precursors of collagen formation, and through nitric oxide synthases it has influences on the bio-molecular inflammatory responses and the local capillary growth and circulation.
Original language | English |
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Article number | 1597 |
Number of pages | 12 |
Journal | Nutrients |
Volume | 10 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2018 |
Keywords
- fracture healing
- nonunion
- arginine
- citrulline
- nitric oxide
- nitric oxide synthase
- NITRIC-OXIDE SYNTHASE
- BONE MORPHOGENETIC PROTEINS
- L-ARGININE
- RISK-FACTORS
- COLLAGEN-SYNTHESIS
- ELDERLY-PATIENTS
- EXPRESSION
- GROWTH
- CLASSIFICATION
- EPIDEMIOLOGY