Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study

M. Dirix; T. van Becelaere; L. Berkenbosch; R. van Baren; R.M. Wijnen; M.H. Wijnen; D.C. van der Zee; H.A. Heij; J.P. Derikx; L.W. van Ernest van Heurn

doi:10.1016/j.jpedsurg.2014.07.014

Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study

M. Dirix
, T. van Becelaere
, L. Berkenbosch
, R. van Baren
, R.M. Wijnen
, M.H. Wijnen
, D.C. van der Zee
, H.A. Heij
, J.P. Derikx
, L.W. van Ernest van Heurn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND/PURPOSE: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. METHODS: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. RESULTS: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p=0.017) CONCLUSIONS: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.

Original language	English
Pages (from-to)	462-464
Number of pages	3
Journal	Journal of Pediatric Surgery
Volume	50
Issue number	3
DOIs	https://doi.org/10.1016/j.jpedsurg.2014.07.014
Publication status	Published - 1 Jan 2015

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Dirix, M., van Becelaere, T., Berkenbosch, L., van Baren, R., Wijnen, R. M., Wijnen, M. H., van der Zee, D. C., Heij, H. A., Derikx, J. P., & van Ernest van Heurn, L. W. (2015). Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study. Journal of Pediatric Surgery, 50(3), 462-464. https://doi.org/10.1016/j.jpedsurg.2014.07.014

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title = "Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study",

abstract = "BACKGROUND/PURPOSE: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. METHODS: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. RESULTS: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80\% and 58\% after one and two years in SCT versus 100\% after two years in CS, p=0.017) CONCLUSIONS: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.",

author = "M. Dirix and \{van Becelaere\}, T. and L. Berkenbosch and \{van Baren\}, R. and R.M. Wijnen and M.H. Wijnen and \{van der Zee\}, D.C. and H.A. Heij and J.P. Derikx and \{van Ernest van Heurn\}, L.W.",

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doi = "10.1016/j.jpedsurg.2014.07.014",

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volume = "50",

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Dirix, M, van Becelaere, T, Berkenbosch, L, van Baren, R, Wijnen, RM, Wijnen, MH, van der Zee, DC, Heij, HA, Derikx, JP & van Ernest van Heurn, LW 2015, 'Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study', Journal of Pediatric Surgery, vol. 50, no. 3, pp. 462-464. https://doi.org/10.1016/j.jpedsurg.2014.07.014

TY - JOUR

T1 - Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study

AU - Dirix, M.

AU - van Becelaere, T.

AU - Berkenbosch, L.

AU - van Baren, R.

AU - Wijnen, R.M.

AU - Wijnen, M.H.

AU - van der Zee, D.C.

AU - Heij, H.A.

AU - Derikx, J.P.

AU - van Ernest van Heurn, L.W.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - BACKGROUND/PURPOSE: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. METHODS: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. RESULTS: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p=0.017) CONCLUSIONS: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.

AB - BACKGROUND/PURPOSE: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. METHODS: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. RESULTS: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p=0.017) CONCLUSIONS: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.

U2 - 10.1016/j.jpedsurg.2014.07.014

DO - 10.1016/j.jpedsurg.2014.07.014

M3 - Article

C2 - 25746708

SN - 0022-3468

VL - 50

SP - 462

EP - 464

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

IS - 3

ER -

Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study

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