Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study

M. Dirix, T. van Becelaere, L. Berkenbosch, R. van Baren, R.M. Wijnen, M.H. Wijnen, D.C. van der Zee, H.A. Heij, J.P. Derikx, L.W. van Ernest van Heurn

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Abstract

BACKGROUND/PURPOSE: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. METHODS: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. RESULTS: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p=0.017) CONCLUSIONS: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.
Original languageEnglish
Pages (from-to)462-464
JournalJournal of Pediatric Surgery
Volume50
Issue number3
DOIs
Publication statusPublished - 1 Jan 2015

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Dirix, M., van Becelaere, T., Berkenbosch, L., van Baren, R., Wijnen, R. M., Wijnen, M. H., van der Zee, D. C., Heij, H. A., Derikx, J. P., & van Ernest van Heurn, L. W. (2015). Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study. Journal of Pediatric Surgery, 50(3), 462-464. https://doi.org/10.1016/j.jpedsurg.2014.07.014