Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS

Karen Ann Ribbons; Patrick McElduff; Cavit Boz; Maria Trojano; Guillermo Izquierdo; Pierre Duquette; Marc Girard; Francois Grand'Maison; Raymond Hupperts; Pierre Grammond; Celia Oreja-Guevara; Thor Petersen; Roberto Bergamaschi; Giorgio Giuliani; Michael Barnett; Vincent van Pesch; Maria-Pia Amato; Gerardo Iuliano; Marcela Fiol; Mark Slee; Freek Verheul; Edgardo Cristiano; Ricardo Fernandez-Bolanos; Maria-Laura Saladino; Maria Edite Rio; Jose Cabrera-Gomez; Helmut Butzkueven; Erik van Munster; Leontien Den Braber-Moerland; Daniele La Spitaleri; Alessandra Lugaresi; Vahid Shaygannejad; Orla Gray; Norma Deri; Raed Alroughani; Jeannette Lechner-Scott

doi:10.1371/journal.pone.0122686

Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS

Karen Ann Ribbons^*
, Patrick McElduff
, Cavit Boz
, Maria Trojano
, Guillermo Izquierdo
, Pierre Duquette
, Marc Girard
, Francois Grand'Maison
, Raymond Hupperts
, Pierre Grammond
, Celia Oreja-Guevara
, Thor Petersen
, Roberto Bergamaschi
, Giorgio Giuliani
, Michael Barnett
, Vincent van Pesch
, Maria-Pia Amato
, Gerardo Iuliano
, Marcela Fiol
, Mark Slee

Freek Verheul, Edgardo Cristiano, Ricardo Fernandez-Bolanos, Maria-Laura Saladino, Maria Edite Rio, Jose Cabrera-Gomez, Helmut Butzkueven, Erik van Munster, Leontien Den Braber-Moerland, Daniele La Spitaleri, Alessandra Lugaresi, Vahid Shaygannejad, Orla Gray, Norma Deri, Raed Alroughani, Jeannette Lechner-Scott

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females.Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS.In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P

Original language	English
Article number	e0122686
Journal	PLOS ONE
Volume	10
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0122686
Publication status	Published - 5 Jun 2015

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Ribbons, K. A., McElduff, P., Boz, C., Trojano, M., Izquierdo, G., Duquette, P., Girard, M., Grand'Maison, F., Hupperts, R., Grammond, P., Oreja-Guevara, C., Petersen, T., Bergamaschi, R., Giuliani, G., Barnett, M., van Pesch, V., Amato, M.-P., Iuliano, G., Fiol, M., ... Lechner-Scott, J. (2015). Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS. PLOS ONE, 10(6), Article e0122686. https://doi.org/10.1371/journal.pone.0122686

@article{e4c9b8ac039c4c028fd5a00fbc2c9e63,

title = "Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS",

abstract = "Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females.Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS.In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P",

author = "Ribbons, \{Karen Ann\} and Patrick McElduff and Cavit Boz and Maria Trojano and Guillermo Izquierdo and Pierre Duquette and Marc Girard and Francois Grand'Maison and Raymond Hupperts and Pierre Grammond and Celia Oreja-Guevara and Thor Petersen and Roberto Bergamaschi and Giorgio Giuliani and Michael Barnett and \{van Pesch\}, Vincent and Maria-Pia Amato and Gerardo Iuliano and Marcela Fiol and Mark Slee and Freek Verheul and Edgardo Cristiano and Ricardo Fernandez-Bolanos and Maria-Laura Saladino and Rio, \{Maria Edite\} and Jose Cabrera-Gomez and Helmut Butzkueven and \{van Munster\}, Erik and \{Den Braber-Moerland\}, Leontien and \{La Spitaleri\}, Daniele and Alessandra Lugaresi and Vahid Shaygannejad and Orla Gray and Norma Deri and Raed Alroughani and Jeannette Lechner-Scott",

year = "2015",

month = jun,

day = "5",

doi = "10.1371/journal.pone.0122686",

language = "English",

volume = "10",

journal = "PLOS ONE",

issn = "1932-6203",

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Ribbons, KA, McElduff, P, Boz, C, Trojano, M, Izquierdo, G, Duquette, P, Girard, M, Grand'Maison, F, Hupperts, R, Grammond, P, Oreja-Guevara, C, Petersen, T, Bergamaschi, R, Giuliani, G, Barnett, M, van Pesch, V, Amato, M-P, Iuliano, G, Fiol, M, Slee, M, Verheul, F, Cristiano, E, Fernandez-Bolanos, R, Saladino, M-L, Rio, ME, Cabrera-Gomez, J, Butzkueven, H, van Munster, E, Den Braber-Moerland, L, La Spitaleri, D, Lugaresi, A, Shaygannejad, V, Gray, O, Deri, N, Alroughani, R & Lechner-Scott, J 2015, 'Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS', PLOS ONE, vol. 10, no. 6, e0122686. https://doi.org/10.1371/journal.pone.0122686

TY - JOUR

T1 - Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS

AU - Ribbons, Karen Ann

AU - McElduff, Patrick

AU - Boz, Cavit

AU - Trojano, Maria

AU - Izquierdo, Guillermo

AU - Duquette, Pierre

AU - Girard, Marc

AU - Grand'Maison, Francois

AU - Hupperts, Raymond

AU - Grammond, Pierre

AU - Oreja-Guevara, Celia

AU - Petersen, Thor

AU - Bergamaschi, Roberto

AU - Giuliani, Giorgio

AU - Barnett, Michael

AU - van Pesch, Vincent

AU - Amato, Maria-Pia

AU - Iuliano, Gerardo

AU - Fiol, Marcela

AU - Slee, Mark

AU - Verheul, Freek

AU - Cristiano, Edgardo

AU - Fernandez-Bolanos, Ricardo

AU - Saladino, Maria-Laura

AU - Rio, Maria Edite

AU - Cabrera-Gomez, Jose

AU - Butzkueven, Helmut

AU - van Munster, Erik

AU - Den Braber-Moerland, Leontien

AU - La Spitaleri, Daniele

AU - Lugaresi, Alessandra

AU - Shaygannejad, Vahid

AU - Gray, Orla

AU - Deri, Norma

AU - Alroughani, Raed

AU - Lechner-Scott, Jeannette

PY - 2015/6/5

Y1 - 2015/6/5

N2 - Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females.Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS.In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P

AB - Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females.Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS.In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P

U2 - 10.1371/journal.pone.0122686

DO - 10.1371/journal.pone.0122686

M3 - Article

SN - 1932-6203

VL - 10

JO - PLOS ONE

JF - PLOS ONE

IS - 6

M1 - e0122686

ER -

Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS

Abstract

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