Magnetic resonance imaging of cervical cancer: prediction of parametrial invasion and treatment response

Jordy Mongula

Research output: ThesisDoctoral ThesisInternal

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Abstract

The choice of therapy (surgery or radiation) in early-stage cervical cancer is based on the stage of the disease. In this thesis we show that a new MRI technique, diffusion-weighted MRI, is able to determine more precisely whether there is or isn’t invasion to surrounding tissue. This results in more patients receiving the correct treatment.
Late-stage cervical cancer is usually treated with radiation and chemotherapy. In a minority (6-7%) of patients, there is an incomplete reaction to the radiation. In selected cases, this group can still be cured through surgery. In this thesis, imaging techniques were used to demonstrate local persistence of cancer. The decrease in volume of the cancer during radiation, as shown on MRIs, was able to predict an incomplete reaction to the radiation. After the radiation, it appeared that predetermined MRI criteria and PET data increased the precision of detecting local persistence of disease. Hopefully these options can be used in the future to select patients who are eligible for additional treatment.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Kruitwagen, Roy, Supervisor
  • Slangen, Brigitte, Co-Supervisor
  • Mihl, Casper, Co-Supervisor
Award date8 Oct 2020
Place of PublicationMaastricht
Publisher
Print ISBNs9789464022421
DOIs
Publication statusPublished - 2020

Keywords

  • cervical cancer
  • MRI
  • parametrial invasion
  • treatment response

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