Magnesium in Chronic Kidney Disease: Should We Care?

Esther R. van de Wal-Visscher, Jeroen P. Kooman, Frank M. van der Sande*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Web of Science)

Abstract

Background: Magnesium (Mg) is an essential cation for multiple processes in the body. The kidney plays a major role in regulating the Mg balance. In a healthy individual, total-body Mg content is kept constant by interactions among intestine, bones and the kidneys. Summary: In case of chronic kidney disease (CKD), renal regulatory mechanisms may be insufficient to balance intestinal Mg absorption. Usually Mg remains normal; however, when glomerular filtration rate declines, changes in serum Mg are observed. Patients with end-stage renal disease on dialysis are largely dependent on the dialysate Mg concentration for maintaining serum Mg and Mg homeostasis. A low Mg is associated with several complications such as hypertension, and vascular calcification, and also associated with an increased risk for both cardiovascular disease (CVD) and non-CVD mortality. Severe hypermagnesaemia is known to cause cardiac conduction defects, neuromuscular effects and muscle weakness; a slightly elevated Mg has been suggested to be beneficial in patients with end-stage renal disease. Key Messages: The role of both low and high Mg, in general, but especially in relation to CKD and dialysis patients is discussed. (c) 2018 S. Karger AG, Basel
Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalBlood Purification
Volume45
Issue number1-3
DOIs
Publication statusPublished - 1 Jan 2018
EventRenal-Research-Institute's 20th International Conference on Dialysis, Advances in Chronic Kidney Disease (CKD) - Lake Buena Vista, FL, Lake Buena Vista
Duration: 1 Jan 2018 → …

Keywords

  • Magnesium
  • Chronic kidney disease
  • (Patho) physiology
  • Haemodialysis
  • Outcome
  • PERITONEAL-DIALYSIS PATIENTS
  • LOWER SERUM MAGNESIUM
  • HEMODIALYSIS-PATIENTS
  • CARDIOVASCULAR MORTALITY
  • SIGNIFICANT PREDICTOR
  • ENDOTHELIAL-CELLS
  • PROTECTIVE ROLE
  • RENAL-FAILURE
  • DOUBLE-BLIND
  • HYPOMAGNESEMIA

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