Macrophage Migration Inhibitory Factor Predicts Outcome in Complex Aortic Surgery

Alexander Gombert*, Christian Stoppe, Ann Christina Foldenauer, Tobias Schuerholz, Lukas Martin, Johannes Kalder, Gereon Schaelte, Gernot Marx, Michael Jacobs, Jochen Grommes

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Web of Science)

Abstract

The perioperative inflammatory response is associated with outcome after complex aortic repair. Macrophage migration inhibitory factor (MIF) shows protective effects in ischemia-reperfusion (IR), but also adverse pro-inflammatory effects in acute inflammation, potentially leading to adverse outcome, which should be investigated in this trial. This prospective study enrolled 52 patients, of whom 29 (55.7%) underwent open repair (OR) and 23 (44.3%) underwent endovascular repair (ER) between 2014 and 2015. MIF serum levels were measured until 72 h post-operatively. We used linear mixed models and ROC analysis to analyze the MIF time-course and its diagnostic ability. Compared to ER, OR induced higher MIF release perioperatively; at 12 h after ICU admission, MIF levels were similar between groups. MIF course was significantly influenced by baseline MIF level (P = 0.0016) and acute physiology and chronic health evaluation (APACHE) II score (P = 0.0005). MIF level at 24 h after ICU admission showed good diagnostic value regarding patient survival [sensitivity, 80.0% (28.4-99.5%); specificity, 51.2% (35.1-67.1%); AUC, 0.688 (0.534-0.816)] and discharge modality [sensitivity, 87.5% (47.3-99.7%); specificity, 73.7% (56.9-86.6%), AUC, 0.789 (0.644-0.896)]. Increased perioperative MIF-levels are related to an increased risk of adverse outcome in complex aortic surgery and may represent a biomarker for risk stratification in complex aortic surgery.

Original languageEnglish
Article number2374
Number of pages14
JournalInternational journal of molecular sciences
Volume18
Issue number11
DOIs
Publication statusPublished - Nov 2017

Keywords

  • macrophage migration inhibitory factor
  • thoracoabdominal aortic aneurysm
  • intensive care unit
  • survival
  • SPINAL-CORD ISCHEMIA
  • ANEURYSM REPAIR
  • ENDOVASCULAR REPAIR
  • INFLAMMATORY RESPONSE
  • FACTOR MIF
  • ATHEROSCLEROSIS
  • EXPRESSION
  • PROTECTION
  • DISEASE
  • SEPSIS

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