Lymphocyte activation in silica-exposed workers

Michelle Rocha-Parise, Leonilda M. B. Santos, Jan G. M. C. Damoiseaux, Ericson Bagatin, Alessandro V. Lido, Cristiane Okuda Torello, Jan W. Cohen Tervaert, Mary L. S. Queiroz*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and ANCA-associated vasculitis. However, the underlying cellular and molecular mechanisms resulting in the increased prevalence of autoimmunity remain elusive. To clarify these mechanisms, we studied various markers of immune activation in individuals occupationally exposed to silica dust, i.e., serum levels of soluble IL-2 receptor (sIL-2R), levels of IL-2, other pro- and anti-inflammatory cytokines and lymphoproliferation. Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-gamma, IL-1 alpha, TNF-alpha, IL-6) as well as anti-inflammatory (IL-10 and TGF-beta) cytokines. Furthermore, silica-exposed individuals presented enhanced lymphoproliferative responses. Our findings provide evidence that the maintenance of immune homeostasis may be disturbed in silica-exposed individuals, possibly resulting in autoimmune disorders.
Original languageEnglish
Pages (from-to)586-591
JournalInternational Journal of Hygiene and Environmental Health
Volume217
Issue number4-5
DOIs
Publication statusPublished - 2014

Keywords

  • Lymphocytes
  • Soluble IL-2 receptor alpha
  • Interleukin-2
  • Silica
  • Cytokines
  • Autoimmunity

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