Lung Function and Risk for Heart Failure Among Older Adults: The Health ABC Study

Vasiliki V. Georgiopoulou*, Andreas P. Kalogeropoulos, Bruce M. Psaty, Nicolas Rodondi, Douglas C. Bauer, Abida B. Butler, Annemarie Koster, Andrew L. Smith, Tamara B. Harris, Anne B Newman, Stephen B Kritchevsky, Javed Butler

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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The impact of abnormal spirometric findings on risk for incident heart failure among older adults without clinically apparent lung disease is not well elucidated.We evaluated the association of baseline lung function with incident heart failure, defined as first hospitalization for heart failure, in 2125 participants of the community-based Health, Aging, and Body Composition (Health ABC) Study (age, 73.6 ? 2.9 years; 50.5% men; 62.3% white; 37.7% black) without prevalent lung disease or heart failure. Abnormal lung function was defined either as forced vital capacity (FVC) or forced expiratory volume in 1(st) second (FEV(1)) to FVC ratio below lower limit of normal. Percent predicted FVC and FEV(1) also were assessed as continuous variables.During follow-up (median, 9.4 years), heart failure developed in 68 of 350 (19.4%) participants with abnormal baseline lung function, as compared with 172 of 1775 (9.7%) participants with normal lung function (hazard ratio [HR] 2.31; 95% confidence interval [CI], 1.74-3.07; P
Original languageEnglish
Pages (from-to)334-341
JournalAmerican Journal of Medicine
Issue number4
Publication statusPublished - Apr 2011


  • Elderly
  • Epidemiology
  • Heart failure
  • Pulmonary function test

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