Lower versus Traditional Treatment Threshold for Neonatal Hypoglycemia

A. A. M. W. van Kempen; P. F. Eskes; D. H. G. M. Nuytemans; J. H. van der Lee; L. M. Dijksman; N. R. van Veenendaal; F. J. P. C. M. van der Hulst; R. M. J. Moonen; L. J. I. Zimmermann; E. P. van't Verlaat; M. van Dongen-van Baal; B. A. Semmekrot; H. G. Stas; R. H. T. van Beek; J. J. Vlietman; P. H. Dijk; J. U. M. Termote; R. C. J. de Jonge; A. C. de Mol; M. W. A. Huysman; J. H. Kok; M. Offringa; N. Boluyt; HypoEXIT Study Group

doi:10.1056/NEJMoa1905593

Lower versus Traditional Treatment Threshold for Neonatal Hypoglycemia

A. A. M. W. van Kempen^*, P. F. Eskes, D. H. G. M. Nuytemans, J. H. van der Lee, L. M. Dijksman, N. R. van Veenendaal, F. J. P. C. M. van der Hulst, R. M. J. Moonen, L. J. I. Zimmermann, E. P. van't Verlaat, M. van Dongen-van Baal, B. A. Semmekrot, H. G. Stas, R. H. T. van Beek, J. J. Vlietman, P. H. Dijk, J. U. M. Termote, R. C. J. de Jonge, A. C. de Mol, M. W. A. HuysmanJ. H. Kok, M. Offringa, N. Boluyt, HypoEXIT Study Group

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

38 Citations (Web of Science)

Abstract

BACKGROUND Worldwide, many newborns who are preterm, small or large for gestational age, or born to mothers with diabetes are screened for hypoglycemia, with a goal of preventing brain injury. However, there is no consensus on a treatment threshold that is safe but also avoids over treatment. METHODS In a multicenter, randomized, noninferiority trial involving 689 otherwise healthy newborns born at 35 weeks of gestation or later and identified as being at risk for hypoglycemia, we compared two threshold values for treatment of asymptomatic moderate hypoglycemia. We sought to determine whether a management strategy that used a lower threshold (treatment administered at a glucose concentration of

Original language	English
Pages (from-to)	534-544
Number of pages	11
Journal	New England Journal of Medicine
Volume	382
Issue number	6
DOIs	https://doi.org/10.1056/NEJMoa1905593
Publication status	Published - 6 Feb 2020

Keywords

VITAMIN-D SUPPLEMENTATION
D DEFICIENCY
ASTHMA
PREGNANCY
DESIGN
WHEEZE
AGE

Access to Document

10.1056/NEJMoa1905593

Cite this

van Kempen, A. A. M. W., Eskes, P. F., Nuytemans, D. H. G. M., van der Lee, J. H., Dijksman, L. M., van Veenendaal, N. R., van der Hulst, F. J. P. C. M., Moonen, R. M. J., Zimmermann, L. J. I., van't Verlaat, E. P., van Dongen-van Baal, M., Semmekrot, B. A., Stas, H. G., van Beek, R. H. T., Vlietman, J. J., Dijk, P. H., Termote, J. U. M., de Jonge, R. C. J., de Mol, A. C., ... HypoEXIT Study Group (2020). Lower versus Traditional Treatment Threshold for Neonatal Hypoglycemia. New England Journal of Medicine, 382(6), 534-544. https://doi.org/10.1056/NEJMoa1905593

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title = "Lower versus Traditional Treatment Threshold for Neonatal Hypoglycemia",

abstract = "BACKGROUND Worldwide, many newborns who are preterm, small or large for gestational age, or born to mothers with diabetes are screened for hypoglycemia, with a goal of preventing brain injury. However, there is no consensus on a treatment threshold that is safe but also avoids over treatment. METHODS In a multicenter, randomized, noninferiority trial involving 689 otherwise healthy newborns born at 35 weeks of gestation or later and identified as being at risk for hypoglycemia, we compared two threshold values for treatment of asymptomatic moderate hypoglycemia. We sought to determine whether a management strategy that used a lower threshold (treatment administered at a glucose concentration of",

keywords = "VITAMIN-D SUPPLEMENTATION, D DEFICIENCY, ASTHMA, PREGNANCY, DESIGN, WHEEZE, AGE",

author = "{van Kempen}, {A. A. M. W.} and Eskes, {P. F.} and Nuytemans, {D. H. G. M.} and {van der Lee}, {J. H.} and Dijksman, {L. M.} and {van Veenendaal}, {N. R.} and {van der Hulst}, {F. J. P. C. M.} and Moonen, {R. M. J.} and Zimmermann, {L. J. I.} and {van't Verlaat}, {E. P.} and {van Dongen-van Baal}, M. and Semmekrot, {B. A.} and Stas, {H. G.} and {van Beek}, {R. H. T.} and Vlietman, {J. J.} and Dijk, {P. H.} and Termote, {J. U. M.} and {de Jonge}, {R. C. J.} and {de Mol}, {A. C.} and Huysman, {M. W. A.} and Kok, {J. H.} and M. Offringa and N. Boluyt and {HypoEXIT Study Group}",

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van Kempen, AAMW, Eskes, PF, Nuytemans, DHGM, van der Lee, JH, Dijksman, LM, van Veenendaal, NR, van der Hulst, FJPCM, Moonen, RMJ, Zimmermann, LJI, van't Verlaat, EP, van Dongen-van Baal, M, Semmekrot, BA, Stas, HG, van Beek, RHT, Vlietman, JJ, Dijk, PH, Termote, JUM, de Jonge, RCJ, de Mol, AC, Huysman, MWA, Kok, JH, Offringa, M, Boluyt, N & HypoEXIT Study Group 2020, 'Lower versus Traditional Treatment Threshold for Neonatal Hypoglycemia', New England Journal of Medicine, vol. 382, no. 6, pp. 534-544. https://doi.org/10.1056/NEJMoa1905593

TY - JOUR

T1 - Lower versus Traditional Treatment Threshold for Neonatal Hypoglycemia

AU - van Kempen, A. A. M. W.

AU - Eskes, P. F.

AU - Nuytemans, D. H. G. M.

AU - van der Lee, J. H.

AU - Dijksman, L. M.

AU - van Veenendaal, N. R.

AU - van der Hulst, F. J. P. C. M.

AU - Moonen, R. M. J.

AU - Zimmermann, L. J. I.

AU - van't Verlaat, E. P.

AU - van Dongen-van Baal, M.

AU - Semmekrot, B. A.

AU - Stas, H. G.

AU - van Beek, R. H. T.

AU - Vlietman, J. J.

AU - Dijk, P. H.

AU - Termote, J. U. M.

AU - de Jonge, R. C. J.

AU - de Mol, A. C.

AU - Huysman, M. W. A.

AU - Kok, J. H.

AU - Offringa, M.

AU - Boluyt, N.

AU - HypoEXIT Study Group

PY - 2020/2/6

Y1 - 2020/2/6

N2 - BACKGROUND Worldwide, many newborns who are preterm, small or large for gestational age, or born to mothers with diabetes are screened for hypoglycemia, with a goal of preventing brain injury. However, there is no consensus on a treatment threshold that is safe but also avoids over treatment. METHODS In a multicenter, randomized, noninferiority trial involving 689 otherwise healthy newborns born at 35 weeks of gestation or later and identified as being at risk for hypoglycemia, we compared two threshold values for treatment of asymptomatic moderate hypoglycemia. We sought to determine whether a management strategy that used a lower threshold (treatment administered at a glucose concentration of

AB - BACKGROUND Worldwide, many newborns who are preterm, small or large for gestational age, or born to mothers with diabetes are screened for hypoglycemia, with a goal of preventing brain injury. However, there is no consensus on a treatment threshold that is safe but also avoids over treatment. METHODS In a multicenter, randomized, noninferiority trial involving 689 otherwise healthy newborns born at 35 weeks of gestation or later and identified as being at risk for hypoglycemia, we compared two threshold values for treatment of asymptomatic moderate hypoglycemia. We sought to determine whether a management strategy that used a lower threshold (treatment administered at a glucose concentration of

KW - VITAMIN-D SUPPLEMENTATION

KW - D DEFICIENCY

KW - ASTHMA

KW - PREGNANCY

KW - DESIGN

KW - WHEEZE

KW - AGE

U2 - 10.1056/NEJMoa1905593

DO - 10.1056/NEJMoa1905593

M3 - Article

C2 - 32023373

VL - 382

SP - 534

EP - 544

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 6

ER -