Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease

Ianthe Piscaer*, Jody M. W. van den Ouweland, Kristina Vermeersch, Niki L. Reynaert, Frits M. E. Franssen, Spencer Keene, Emiel F. M. Wouters, Wim Janssens, Cees Vermeer, Rob Janssen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Web of Science)

Abstract

Elastin degradation is accelerated in chronic obstructive pulmonary disease (COPD) and is partially regulated by Matrix Gla Protein (MGP), via a vitamin K-dependent pathway. The aim was to assess vitamin K status in COPD as well as associations between vitamin K status, elastin degradation, lung function parameters and mortality. A total of 192 COPD patients and 186 age-matched controls were included. In addition to this, 290 COPD patients from a second independent longitudinal cohort were also included. Vitamin K status was assessed by measuring plasma inactive MGP levels and rates of elastin degradation by measuring plasma desmosine levels. Reduced vitamin K status was found in COPD patients compared to smoking controls (p <0.0005) and controls who had never smoked (p = 0.001). Vitamin K status was inversely associated with desmosine (cohort 1: p = 0.001; cohort 2: p = 0.004). Only few significant associations between vitamin K status and lung function parameters were found. Mortality was higher in COPD patients within the quartile with the lowest vitamin K status compared to those within the other quartiles (hazard ratio 1.85, 95% confidence interval (CI), 1.21-2.83, p = 0.005). In conclusion, we demonstrated reduced vitamin K status in COPD and an inverse association between vitamin K status and elastin degradation rate. Our results therefore suggest a potential role of vitamin K in COPD pathogenesis.

Original languageEnglish
Article number1116
Number of pages14
JournalJournal of Clinical Medicine
Volume8
Issue number8
DOIs
Publication statusPublished - Aug 2019

Keywords

  • chronic obstructive pulmonary disease
  • desmosine
  • elastin degradation
  • matrix Gla protein
  • vitamin K
  • MATRIX GLA-PROTEIN
  • MORTALITY
  • CALCIFICATION
  • COPD
  • LUNG
  • DESMOSINE
  • BIOMARKER
  • SURVIVAL
  • MODEL
  • RISK

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