Low vitamin D status is associated with reduced muscle mass and impaired physical performance in frail elderly people.

M. Tieland, E.M. Brouwer Brolsma, C. Nienaber Rousseau, L.J. van Loon, L.C. de Groot

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background/Objectives:Serum 25-hydroxyvitamin D (25(OH)D) status has associated with muscle mass, strength and physical performance in people. Yet, in pre-frail and frail elderly people this association has studied. The objective of this study was to explore the association vitamin D intake and serum 25(OH)D status with muscle mass, strength and performance in a pre-frail and frail elderly cross-sectional study included 127 pre-frail and frail elderly people in Netherlands. Whole body and appendicular lean mass (ALM) (dual energy X- absorptiometry), leg strength (one repetition maximum), handgrip physical performance (short physical performance battery) were measured, blood samples were collected for the assessment of serum 25(OH)D status chromatography-tandem mass spectrometry). In addition, habitual dietary (3-day food records) and physical activity data (accelerometers) were collected.Results:In total, 53% of the participants had a serum 25(OH)D below 50 nmol/l. After adjustment for confounding factors, 25(OH)D associated with ALM (beta=0.012, P=0.05) and with physical performance (beta=0.020, P<0.05). Vitamin D intake was associated with physical (beta=0.18, P<0.05) but not with ALM (P>0.05).Conclusion:In this frail population, 25(OH)D status is low and suggests a modest association with ALM and impaired physical performance. In addition, vitamin D intake associated with impaired physical performance. Our findings highlight for well-designed intervention trials to assess the impact of vitamin D supplementation on 25(OH)D status, muscle mass and physical performance pre-frail and frail elderly people.European Journal of Clinical online publication, 14 August 2013; doi:10.1038/ejcn.2013.144.
Original languageEnglish
Pages (from-to)1050-1055
JournalEuropean Journal of Clinical Nutrition
Volume67
Issue number10
DOIs
Publication statusPublished - 1 Jan 2013

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