Low Risk of Development of a Regional Recurrence After an Unsuccessful Repeat Sentinel Lymph Node Biopsy in Patients with Ipsilateral Breast Tumor Recurrence

Ingrid G. M. Poodt; Coco J. E. F. Walstra; Guusje Vugts; Adriana J. G. Maaskant-Braat; Adri C. Voogd; Robert-Jan Schipper; Grard A. P. Nieuwenhuijzen; R. M. H. Roumen; E. J. T. Luiten; E. J. T. Rutgers; M. T. F. D. Vrancken-Peeters; M. Bessems; M. Klaase; S. Muller; A. B. Francken; T. Van Dalen; L. Jansen; S. A. Koopal; Y. L. J. Vissers; M. L. Smidt; J. W. S. Merkus; C. M. E. Contant; P. H. Veldman; E. M. H. Linthorst-Niers; J. R. van der Sijp; O. R. Guicherit; L. B. Koppert; A. M. Bosch; L. J. A. Strobbe; M. S. Schlooz-Vries; I. E. Arntz; J. A. van Essen; J. W. D. de Waard; B. C. Vrouenraets; B. van Ooijen; Sentinel Node Recurrent Breast

doi:10.1245/s10434-019-07272-4

Low Risk of Development of a Regional Recurrence After an Unsuccessful Repeat Sentinel Lymph Node Biopsy in Patients with Ipsilateral Breast Tumor Recurrence

Ingrid G. M. Poodt^*, Coco J. E. F. Walstra, Guusje Vugts, Adriana J. G. Maaskant-Braat, Adri C. Voogd, Robert-Jan Schipper, Grard A. P. Nieuwenhuijzen, R. M. H. Roumen, E. J. T. Luiten, E. J. T. Rutgers, M. T. F. D. Vrancken-Peeters, M. Bessems, M. Klaase, S. Muller, A. B. Francken, T. Van Dalen, L. Jansen, S. A. Koopal, Y. L. J. Vissers, M. L. SmidtJ. W. S. Merkus, C. M. E. Contant, P. H. Veldman, E. M. H. Linthorst-Niers, J. R. van der Sijp, O. R. Guicherit, L. B. Koppert, A. M. Bosch, L. J. A. Strobbe, M. S. Schlooz-Vries, I. E. Arntz, J. A. van Essen, J. W. D. de Waard, B. C. Vrouenraets, B. van Ooijen, Sentinel Node Recurrent Breast

^*Corresponding author for this work

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Abstract

BackgroundUnlike sentinel lymph node biopsy (SLNB) in the primary setting, the repeat SLNB (rSLNB) in patients with ipsilateral breast tumor recurrence (IBTR) is challenging, because it is difficult to visualize and/or harvest a sentinel lymph node in every patient. Regional treatments options and safety in terms of regional disease control after such an unsuccessful rSLNB remain unclear. This study assesses factors associated with the performance of axillary lymph node dissection (ALND) after unsuccessful rSLNB and evaluates the occurrence of regional recurrences.MethodsData were obtained from the Sentinel Node and Recurrent Breast Cancer (SNARB) study. In 239 patients, the rSLNB was unsuccessful, of whom 60 patients underwent ipsilateral ALND.ResultsA shorter time interval between primary treatment and IBTR, and a primary negative SLNB were significantly associated with a higher probability to be treated with ALND after unsuccessful rSLNB (P0.05).ConclusionsThe present study demonstrates that the risk of regional recurrence in patients with an IBTR and an unsuccessful rSLNB is negligible, irrespective of the use of ALND. This suggests that there is no need for additional treatment of the axilla after an unsuccessful rSLNB.

Original language	English
Pages (from-to)	2417-2427
Number of pages	11
Journal	Annals of Surgical Oncology
Volume	26
Issue number	8
DOIs	https://doi.org/10.1245/s10434-019-07272-4
Publication status	Published - Aug 2019

Keywords

EUROPEAN INSTITUTE
CANCER
TRIAL
RADIOTHERAPY
METASTASIS
FIBROSIS
SURGERY
AXILLA
WOMEN

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Poodt, I. G. M., Walstra, C. J. E. F., Vugts, G., Maaskant-Braat, A. J. G., Voogd, A. C., Schipper, R.-J., Nieuwenhuijzen, G. A. P., Roumen, R. M. H., Luiten, E. J. T., Rutgers, E. J. T., Vrancken-Peeters, M. T. F. D., Bessems, M., Klaase, M., Muller, S., Francken, A. B., Van Dalen, T., Jansen, L., Koopal, S. A., Vissers, Y. L. J., ... Sentinel Node Recurrent Breast (2019). Low Risk of Development of a Regional Recurrence After an Unsuccessful Repeat Sentinel Lymph Node Biopsy in Patients with Ipsilateral Breast Tumor Recurrence. Annals of Surgical Oncology, 26(8), 2417-2427. https://doi.org/10.1245/s10434-019-07272-4

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title = "Low Risk of Development of a Regional Recurrence After an Unsuccessful Repeat Sentinel Lymph Node Biopsy in Patients with Ipsilateral Breast Tumor Recurrence",

abstract = "BackgroundUnlike sentinel lymph node biopsy (SLNB) in the primary setting, the repeat SLNB (rSLNB) in patients with ipsilateral breast tumor recurrence (IBTR) is challenging, because it is difficult to visualize and/or harvest a sentinel lymph node in every patient. Regional treatments options and safety in terms of regional disease control after such an unsuccessful rSLNB remain unclear. This study assesses factors associated with the performance of axillary lymph node dissection (ALND) after unsuccessful rSLNB and evaluates the occurrence of regional recurrences.MethodsData were obtained from the Sentinel Node and Recurrent Breast Cancer (SNARB) study. In 239 patients, the rSLNB was unsuccessful, of whom 60 patients underwent ipsilateral ALND.ResultsA shorter time interval between primary treatment and IBTR, and a primary negative SLNB were significantly associated with a higher probability to be treated with ALND after unsuccessful rSLNB (P0.05).ConclusionsThe present study demonstrates that the risk of regional recurrence in patients with an IBTR and an unsuccessful rSLNB is negligible, irrespective of the use of ALND. This suggests that there is no need for additional treatment of the axilla after an unsuccessful rSLNB.",

keywords = "EUROPEAN INSTITUTE, CANCER, TRIAL, RADIOTHERAPY, METASTASIS, FIBROSIS, SURGERY, AXILLA, WOMEN",

author = "Poodt, {Ingrid G. M.} and Walstra, {Coco J. E. F.} and Guusje Vugts and Maaskant-Braat, {Adriana J. G.} and Voogd, {Adri C.} and Robert-Jan Schipper and Nieuwenhuijzen, {Grard A. P.} and Roumen, {R. M. H.} and Luiten, {E. J. T.} and Rutgers, {E. J. T.} and Vrancken-Peeters, {M. T. F. D.} and M. Bessems and M. Klaase and S. Muller and Francken, {A. B.} and {Van Dalen}, T. and L. Jansen and Koopal, {S. A.} and Vissers, {Y. L. J.} and Smidt, {M. L.} and Merkus, {J. W. S.} and Contant, {C. M. E.} and Veldman, {P. H.} and Linthorst-Niers, {E. M. H.} and {van der Sijp}, {J. R.} and Guicherit, {O. R.} and Koppert, {L. B.} and Bosch, {A. M.} and Strobbe, {L. J. A.} and Schlooz-Vries, {M. S.} and Arntz, {I. E.} and {van Essen}, {J. A.} and {de Waard}, {J. W. D.} and Vrouenraets, {B. C.} and {van Ooijen}, B. and {Sentinel Node Recurrent Breast}",

note = "Publisher Copyright: {\textcopyright} 2019, Society of Surgical Oncology.",

year = "2019",

month = aug,

doi = "10.1245/s10434-019-07272-4",

language = "English",

volume = "26",

pages = "2417--2427",

journal = "Annals of Surgical Oncology",

issn = "1068-9265",

publisher = "Springer, Cham",

number = "8",

}

Poodt, IGM, Walstra, CJEF, Vugts, G, Maaskant-Braat, AJG, Voogd, AC, Schipper, R-J, Nieuwenhuijzen, GAP, Roumen, RMH, Luiten, EJT, Rutgers, EJT, Vrancken-Peeters, MTFD, Bessems, M, Klaase, M, Muller, S, Francken, AB, Van Dalen, T, Jansen, L, Koopal, SA, Vissers, YLJ, Smidt, ML, Merkus, JWS, Contant, CME, Veldman, PH, Linthorst-Niers, EMH, van der Sijp, JR, Guicherit, OR, Koppert, LB, Bosch, AM, Strobbe, LJA, Schlooz-Vries, MS, Arntz, IE, van Essen, JA, de Waard, JWD, Vrouenraets, BC, van Ooijen, B & Sentinel Node Recurrent Breast 2019, 'Low Risk of Development of a Regional Recurrence After an Unsuccessful Repeat Sentinel Lymph Node Biopsy in Patients with Ipsilateral Breast Tumor Recurrence', Annals of Surgical Oncology, vol. 26, no. 8, pp. 2417-2427. https://doi.org/10.1245/s10434-019-07272-4

Low Risk of Development of a Regional Recurrence After an Unsuccessful Repeat Sentinel Lymph Node Biopsy in Patients with Ipsilateral Breast Tumor Recurrence. / Poodt, Ingrid G. M.; Walstra, Coco J. E. F.; Vugts, Guusje et al.
In: Annals of Surgical Oncology, Vol. 26, No. 8, 08.2019, p. 2417-2427.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Low Risk of Development of a Regional Recurrence After an Unsuccessful Repeat Sentinel Lymph Node Biopsy in Patients with Ipsilateral Breast Tumor Recurrence

AU - Poodt, Ingrid G. M.

AU - Walstra, Coco J. E. F.

AU - Vugts, Guusje

AU - Maaskant-Braat, Adriana J. G.

AU - Voogd, Adri C.

AU - Schipper, Robert-Jan

AU - Nieuwenhuijzen, Grard A. P.

AU - Roumen, R. M. H.

AU - Luiten, E. J. T.

AU - Rutgers, E. J. T.

AU - Vrancken-Peeters, M. T. F. D.

AU - Bessems, M.

AU - Klaase, M.

AU - Muller, S.

AU - Francken, A. B.

AU - Van Dalen, T.

AU - Jansen, L.

AU - Koopal, S. A.

AU - Vissers, Y. L. J.

AU - Smidt, M. L.

AU - Merkus, J. W. S.

AU - Contant, C. M. E.

AU - Veldman, P. H.

AU - Linthorst-Niers, E. M. H.

AU - van der Sijp, J. R.

AU - Guicherit, O. R.

AU - Koppert, L. B.

AU - Bosch, A. M.

AU - Strobbe, L. J. A.

AU - Schlooz-Vries, M. S.

AU - Arntz, I. E.

AU - van Essen, J. A.

AU - de Waard, J. W. D.

AU - Vrouenraets, B. C.

AU - van Ooijen, B.

AU - Sentinel Node Recurrent Breast

PY - 2019/8

Y1 - 2019/8

N2 - BackgroundUnlike sentinel lymph node biopsy (SLNB) in the primary setting, the repeat SLNB (rSLNB) in patients with ipsilateral breast tumor recurrence (IBTR) is challenging, because it is difficult to visualize and/or harvest a sentinel lymph node in every patient. Regional treatments options and safety in terms of regional disease control after such an unsuccessful rSLNB remain unclear. This study assesses factors associated with the performance of axillary lymph node dissection (ALND) after unsuccessful rSLNB and evaluates the occurrence of regional recurrences.MethodsData were obtained from the Sentinel Node and Recurrent Breast Cancer (SNARB) study. In 239 patients, the rSLNB was unsuccessful, of whom 60 patients underwent ipsilateral ALND.ResultsA shorter time interval between primary treatment and IBTR, and a primary negative SLNB were significantly associated with a higher probability to be treated with ALND after unsuccessful rSLNB (P0.05).ConclusionsThe present study demonstrates that the risk of regional recurrence in patients with an IBTR and an unsuccessful rSLNB is negligible, irrespective of the use of ALND. This suggests that there is no need for additional treatment of the axilla after an unsuccessful rSLNB.

AB - BackgroundUnlike sentinel lymph node biopsy (SLNB) in the primary setting, the repeat SLNB (rSLNB) in patients with ipsilateral breast tumor recurrence (IBTR) is challenging, because it is difficult to visualize and/or harvest a sentinel lymph node in every patient. Regional treatments options and safety in terms of regional disease control after such an unsuccessful rSLNB remain unclear. This study assesses factors associated with the performance of axillary lymph node dissection (ALND) after unsuccessful rSLNB and evaluates the occurrence of regional recurrences.MethodsData were obtained from the Sentinel Node and Recurrent Breast Cancer (SNARB) study. In 239 patients, the rSLNB was unsuccessful, of whom 60 patients underwent ipsilateral ALND.ResultsA shorter time interval between primary treatment and IBTR, and a primary negative SLNB were significantly associated with a higher probability to be treated with ALND after unsuccessful rSLNB (P0.05).ConclusionsThe present study demonstrates that the risk of regional recurrence in patients with an IBTR and an unsuccessful rSLNB is negligible, irrespective of the use of ALND. This suggests that there is no need for additional treatment of the axilla after an unsuccessful rSLNB.

KW - EUROPEAN INSTITUTE

KW - CANCER

KW - TRIAL

KW - RADIOTHERAPY

KW - METASTASIS

KW - FIBROSIS

KW - SURGERY

KW - AXILLA

KW - WOMEN

U2 - 10.1245/s10434-019-07272-4

DO - 10.1245/s10434-019-07272-4

M3 - Article

SN - 1068-9265

VL - 26

SP - 2417

EP - 2427

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

IS - 8

ER -

Low Risk of Development of a Regional Recurrence After an Unsuccessful Repeat Sentinel Lymph Node Biopsy in Patients with Ipsilateral Breast Tumor Recurrence

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Keywords

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