Abstract
BackgroundIn cancer patients with a poor prognosis, low skeletal muscle radiographic density is associated with higher mortality. Whether this association also holds for early-stage cancer is not very clear. We aimed to study the association between skeletal muscle density and overall mortality among early-stage (stage I-III) colorectal cancer (CRC) patients. Furthermore, we investigated the association between skeletal muscle density and both CRC-specific mortality and disease-free survival in a subset of the study population.MethodsSkeletal muscle density was assessed in 1681 early-stage CRC patients, diagnosed between 2006 and 2015, using pre-operative computed tomography images. Adjusted Cox proportional hazard models were used to evaluate the association between muscle density and overall mortality, CRC-specific mortality and disease-free survival.ResultsThe median follow-up time was 48 months (range 0-119months). Low muscle density was detected in 39% of CRC patients. Low muscle density was significantly associated with higher mortality (low vs. normal: adjusted HR 1.91, 95% CI 1.53-2.38). After stratification for comorbidities, the association was highest in patients with 2 comorbidities (HR 2.11, 95% CI 1.55-2.87). Furthermore, low skeletal muscle density was significantly associated with poorer disease-free survival (HR 1.68, 95% CI 1.14-2.47), but not with CRC-specific mortality (HR 1.68, 95% CI 0.89-3.17) in a subset of the study population.ConclusionIn early-stage CRC patients, low muscle density was significantly associated with higher overall mortality, and worse disease-free survival.
Original language | English |
---|---|
Pages (from-to) | 2139-2147 |
Number of pages | 9 |
Journal | Journal of Cancer Research and Clinical Oncology |
Volume | 144 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2018 |
Keywords
- Colorectal cancer
- Skeletal muscle density
- Mortality
- Survival
- SKELETAL-MUSCLE
- ATTENUATION
- OBESITY
- CHEMOTHERAPY
- TOMOGRAPHY
- CARCINOMA
- ADIPOSITY
- HEALTH