Low profile high value target: The role of OxLDL in cancer

Albert V. Bitorina; Yvonne Oligschlaeger; Ronit Shiri-Sverdlov; Jan Theys

doi:10.1016/j.bbalip.2019.158518

Low profile high value target: The role of OxLDL in cancer

Albert V. Bitorina, Yvonne Oligschlaeger, Ronit Shiri-Sverdlov^*, Jan Theys^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Unhealthy Western-type diet and physical inactivity are highly associated with the current obesity epidemic and its related metabolic diseases such as atherosclerosis and non-alcoholic steatohepatitis. In addition, increasing evidence indicates that obesity is also a major risk factor for several types of common cancers. Recent studies have provided correlative support that disturbed lipid metabolism plays a role in cancer risk and development, pointing towards parallels in metabolic derangements between metabolic diseases and cancer. An important feature of disturbed lipid metabolism is the increase in circulating low-density lipoproteins, which can be oxidized (oxLDL). Elevated oxLDL and the level of its receptors have been positively associated with increased risk of various types of cancer. This review discusses the pro-oncogenic role of oxLDL in tumor development, progression and potential therapies, and provides insights into the underlying mechanisms.

Original language	English
Article number	158518
Number of pages	9
Journal	Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids
Volume	1864
Issue number	12
DOIs	https://doi.org/10.1016/j.bbalip.2019.158518
Publication status	Published - Dec 2019

Keywords

Cancer
Oxidized low-density lipoprotein
Carcinogenesis
Metastasis
Chemotherapy
LOW-DENSITY-LIPOPROTEIN
EPITHELIAL-MESENCHYMAL TRANSITION
OXIDIZED LDL RECEPTOR-1
LIVER X RECEPTORS
COLORECTAL-CANCER
PANCREATIC-CANCER
OXIDATIVE STRESS
GASTRIC-CANCER
CELLS
RISK

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@article{434bf527f1a04041a7b1343e0e00115b,

title = "Low profile high value target: The role of OxLDL in cancer",

abstract = "Unhealthy Western-type diet and physical inactivity are highly associated with the current obesity epidemic and its related metabolic diseases such as atherosclerosis and non-alcoholic steatohepatitis. In addition, increasing evidence indicates that obesity is also a major risk factor for several types of common cancers. Recent studies have provided correlative support that disturbed lipid metabolism plays a role in cancer risk and development, pointing towards parallels in metabolic derangements between metabolic diseases and cancer. An important feature of disturbed lipid metabolism is the increase in circulating low-density lipoproteins, which can be oxidized (oxLDL). Elevated oxLDL and the level of its receptors have been positively associated with increased risk of various types of cancer. This review discusses the pro-oncogenic role of oxLDL in tumor development, progression and potential therapies, and provides insights into the underlying mechanisms.",

keywords = "Cancer, Oxidized low-density lipoprotein, Carcinogenesis, Metastasis, Chemotherapy, LOW-DENSITY-LIPOPROTEIN, EPITHELIAL-MESENCHYMAL TRANSITION, OXIDIZED LDL RECEPTOR-1, LIVER X RECEPTORS, COLORECTAL-CANCER, PANCREATIC-CANCER, OXIDATIVE STRESS, GASTRIC-CANCER, CELLS, RISK",

author = "Bitorina, {Albert V.} and Yvonne Oligschlaeger and Ronit Shiri-Sverdlov and Jan Theys",

note = "Funding Information: We acknowledge the contribution of all authors cited. We thank all people from the Shiri-Sverdlov and Theys research groups for their contribution. This research was supported by the CVON IN-CONTROL grant (CVON2012-03), the Dutch Organisation for Scientific Research (NWO; Vidi grant no. 016.126.327), ASPASIA (grant no. 015.008.043), TKI-LSH (grant no. 40-41200-98-9306), Dutch Cancer Society (KWF grant no. 10820) and VCK (grant no. Swu16.0057-VT). The funding bodies had no role in the preparation of this manuscript or the decision to publish. Funding Information: This research was supported by the CVON IN-CONTROL grant ( CVON2012-03 ), the Dutch Organisation for Scientific Research (NWO; Vidi grant no. 016.126.327 ), ASPASIA (grant no. 015.008.043 ), TKI-LSH (grant no. 40-41200-98-9306 ), Dutch Cancer Society (KWF grant no. 10820 ) and VCK (grant no. Swu16.0057-VT ). The funding bodies had no role in the preparation of this manuscript or the decision to publish. Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = dec,

doi = "10.1016/j.bbalip.2019.158518",

language = "English",

volume = "1864",

journal = "Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids",

issn = "1388-1981",

publisher = "Elsevier B.V.",

number = "12",

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TY - JOUR

T1 - Low profile high value target

T2 - The role of OxLDL in cancer

AU - Bitorina, Albert V.

AU - Oligschlaeger, Yvonne

AU - Shiri-Sverdlov, Ronit

AU - Theys, Jan

N1 - Funding Information: We acknowledge the contribution of all authors cited. We thank all people from the Shiri-Sverdlov and Theys research groups for their contribution. This research was supported by the CVON IN-CONTROL grant (CVON2012-03), the Dutch Organisation for Scientific Research (NWO; Vidi grant no. 016.126.327), ASPASIA (grant no. 015.008.043), TKI-LSH (grant no. 40-41200-98-9306), Dutch Cancer Society (KWF grant no. 10820) and VCK (grant no. Swu16.0057-VT). The funding bodies had no role in the preparation of this manuscript or the decision to publish. Funding Information: This research was supported by the CVON IN-CONTROL grant ( CVON2012-03 ), the Dutch Organisation for Scientific Research (NWO; Vidi grant no. 016.126.327 ), ASPASIA (grant no. 015.008.043 ), TKI-LSH (grant no. 40-41200-98-9306 ), Dutch Cancer Society (KWF grant no. 10820 ) and VCK (grant no. Swu16.0057-VT ). The funding bodies had no role in the preparation of this manuscript or the decision to publish. Publisher Copyright: © 2019 The Authors

PY - 2019/12

Y1 - 2019/12

N2 - Unhealthy Western-type diet and physical inactivity are highly associated with the current obesity epidemic and its related metabolic diseases such as atherosclerosis and non-alcoholic steatohepatitis. In addition, increasing evidence indicates that obesity is also a major risk factor for several types of common cancers. Recent studies have provided correlative support that disturbed lipid metabolism plays a role in cancer risk and development, pointing towards parallels in metabolic derangements between metabolic diseases and cancer. An important feature of disturbed lipid metabolism is the increase in circulating low-density lipoproteins, which can be oxidized (oxLDL). Elevated oxLDL and the level of its receptors have been positively associated with increased risk of various types of cancer. This review discusses the pro-oncogenic role of oxLDL in tumor development, progression and potential therapies, and provides insights into the underlying mechanisms.

AB - Unhealthy Western-type diet and physical inactivity are highly associated with the current obesity epidemic and its related metabolic diseases such as atherosclerosis and non-alcoholic steatohepatitis. In addition, increasing evidence indicates that obesity is also a major risk factor for several types of common cancers. Recent studies have provided correlative support that disturbed lipid metabolism plays a role in cancer risk and development, pointing towards parallels in metabolic derangements between metabolic diseases and cancer. An important feature of disturbed lipid metabolism is the increase in circulating low-density lipoproteins, which can be oxidized (oxLDL). Elevated oxLDL and the level of its receptors have been positively associated with increased risk of various types of cancer. This review discusses the pro-oncogenic role of oxLDL in tumor development, progression and potential therapies, and provides insights into the underlying mechanisms.

KW - Cancer

KW - Oxidized low-density lipoprotein

KW - Carcinogenesis

KW - Metastasis

KW - Chemotherapy

KW - LOW-DENSITY-LIPOPROTEIN

KW - EPITHELIAL-MESENCHYMAL TRANSITION

KW - OXIDIZED LDL RECEPTOR-1

KW - LIVER X RECEPTORS

KW - COLORECTAL-CANCER

KW - PANCREATIC-CANCER

KW - OXIDATIVE STRESS

KW - GASTRIC-CANCER

KW - CELLS

KW - RISK

U2 - 10.1016/j.bbalip.2019.158518

DO - 10.1016/j.bbalip.2019.158518

M3 - (Systematic) Review article

C2 - 31479734

SN - 1388-1981

VL - 1864

JO - Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids

IS - 12

M1 - 158518

ER -

Low profile high value target: The role of OxLDL in cancer

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Keywords

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