Low profile high value target: The role of OxLDL in cancer

Albert V. Bitorina, Yvonne Oligschlaeger, Ronit Shiri-Sverdlov*, Jan Theys*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

16 Citations (Web of Science)

Abstract

Unhealthy Western-type diet and physical inactivity are highly associated with the current obesity epidemic and its related metabolic diseases such as atherosclerosis and non-alcoholic steatohepatitis. In addition, increasing evidence indicates that obesity is also a major risk factor for several types of common cancers. Recent studies have provided correlative support that disturbed lipid metabolism plays a role in cancer risk and development, pointing towards parallels in metabolic derangements between metabolic diseases and cancer. An important feature of disturbed lipid metabolism is the increase in circulating low-density lipoproteins, which can be oxidized (oxLDL). Elevated oxLDL and the level of its receptors have been positively associated with increased risk of various types of cancer. This review discusses the pro-oncogenic role of oxLDL in tumor development, progression and potential therapies, and provides insights into the underlying mechanisms.

Original languageEnglish
Article number158518
Number of pages9
JournalBiochimica et Biophysica Acta-Molecular and Cell Biology of Lipids
Volume1864
Issue number12
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Cancer
  • Oxidized low-density lipoprotein
  • Carcinogenesis
  • Metastasis
  • Chemotherapy
  • LOW-DENSITY-LIPOPROTEIN
  • EPITHELIAL-MESENCHYMAL TRANSITION
  • OXIDIZED LDL RECEPTOR-1
  • LIVER X RECEPTORS
  • COLORECTAL-CANCER
  • PANCREATIC-CANCER
  • OXIDATIVE STRESS
  • GASTRIC-CANCER
  • CELLS
  • RISK

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