TY - JOUR
T1 - Low Plasma Volume and Increased Pressure Load Relate to Concentric Left Ventricular Remodeling After Preeclampsia
T2 - A Longitudinal Study
AU - Breetveld, Nicolette M.
AU - Alers, Robert-Jan
AU - Geerts, Lauren
AU - van Kuijk, Sander M. J.
AU - van Dijk, Arie P.
AU - van der Vlugt, Maureen J.
AU - Heidema, Wieteke M.
AU - van Neer, Jolijn
AU - van Empel, Vanessa P. M.
AU - Brunner-La Rocca, Hans-Peter
AU - Scholten, Ralph R.
AU - Ghossein-Doha, Chahinda
AU - Spaanderman, Marc E. A.
N1 - Funding Information:
The study topic receives financial support from the "Nederlandse Hartstichting" (Dutch Heart Foundation).
Publisher Copyright:
© 2020 The Authors.
PY - 2020/10/20
Y1 - 2020/10/20
N2 - Background During uncomplicated pregnancy, left ventricular remodeling occurs in an eccentric way. In contrast, during preeclamptic gestation, the left ventricle hypertrophies concentrically, concurrent with loss in circulatory volume and increased blood pressure. Concentric cardiac structure persists in a substantial proportion of women and may be associated with pressure and volume load after preeclampsia. We hypothesize that low volume load, as indicated by plasma volume (PV) after preeclampsia and increased pressure load, is associated with remote concentric remodeling. Methods and Results In this longitudinal cohort study, we included 100 formerly preeclamptic women. Two visits were performed: at 0.8 years postpartum and at 4.8 years postpartum. During visit 1, we measured blood pressure and PV (I(125)dilution technique, low PV 0.42 and left ventricular mass index
AB - Background During uncomplicated pregnancy, left ventricular remodeling occurs in an eccentric way. In contrast, during preeclamptic gestation, the left ventricle hypertrophies concentrically, concurrent with loss in circulatory volume and increased blood pressure. Concentric cardiac structure persists in a substantial proportion of women and may be associated with pressure and volume load after preeclampsia. We hypothesize that low volume load, as indicated by plasma volume (PV) after preeclampsia and increased pressure load, is associated with remote concentric remodeling. Methods and Results In this longitudinal cohort study, we included 100 formerly preeclamptic women. Two visits were performed: at 0.8 years postpartum and at 4.8 years postpartum. During visit 1, we measured blood pressure and PV (I(125)dilution technique, low PV 0.42 and left ventricular mass index
KW - blood pressure
KW - concentric remodeling
KW - echocardiography
KW - plasma volume
KW - preeclampsia
KW - ECHOCARDIOGRAPHY
KW - RECOMMENDATIONS
KW - DISEASE
U2 - 10.1161/JAHA.119.015043
DO - 10.1161/JAHA.119.015043
M3 - Article
C2 - 32924785
SN - 2047-9980
VL - 9
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 19
M1 - 015043
ER -