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Low Levels of Mutant Ubiquitin Are Degraded by the Proteasome In Vivo
Paula van Tijn
, Marian C. Verhage
, Barbara Hobo
, Fred W. van Leeuwen
, David F. Fischer
*
*
Corresponding author for this work
MHeNs - Mental Health and Neuroscience Research Institute
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INIS
levels
100%
proteins
100%
in vivo
100%
mutants
100%
nervous system diseases
60%
accumulation
60%
diseases
40%
substrates
40%
brain
20%
mice
20%
populations
20%
inhibition
20%
pathogenesis
20%
in vitro
20%
infusion
20%
transgenic mice
20%
deposits
20%
Keyphrases
UBB+1
100%
Mutant Ubiquitin
100%
Expression Level
33%
Neurodegenerative Diseases
22%
Protease Inhibitors
22%
Low Expression
22%
Ubiquitin
11%
Alzheimer's Disease
11%
Normal Brain
11%
Cell Population
11%
High-level Expression
11%
Ubiquitin-proteasome System
11%
Proteasomal Degradation
11%
Neuronal Cells
11%
Polyglutamine Disease
11%
Neuropathology
11%
Intrinsic Properties
11%
Intracellular Protein
11%
Tauopathy
11%
Transgenic Lines
11%
Proteasome Inhibition
11%
Lactacystin
11%
Degradation in Vitro
11%
Intracranial Infusion
11%
Protein Turnover
11%
Ubiquitin Fusion
11%
Endogenous Biomarkers
11%
Disease-related
11%
Proteasome Dysfunction
11%
Transgenic Mouse Lines
11%
Neuroscience
In Vivo
100%
Proteasome
100%
Ubiquitin
100%
Neurodegenerative Disorder
40%
Proteasome Inhibitor
40%
In Vitro
20%
Alzheimer's Disease
20%
Polyglutamine
20%
Cell Protein
20%
Tauopathy
20%
Biochemistry, Genetics and Molecular Biology
Ubiquitin
100%
Proteasome
100%
Proteasome Inhibitor
40%
Protein Degradation
20%
Transgenic Mouse
20%
Transgenics
20%