Low-dose-aspirin usage among women with an increased preeclampsia risk: A prospective cohort study

Pim van Montfort*, Hubertina C. J. Scheepers, Ivo M. A. van Dooren, Linda J. E. Meertens, Maartje Zelis, Iris M. Zwaan, Marc E. A. Spaanderman, Luc J. M. Smits

*Corresponding author for this work

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Introduction Low-dose aspirin (LDA) prophylaxis has been shown to reduce women's preeclampsia risk. Evidence regarding LDA adherence rates of pregnant women is based almost exclusively on clinical trials, giving a potentially biased picture. Moreover, these studies do not report on determinants of adherence. Since 2017, obstetric healthcare professionals in a Dutch region have assessed women's preeclampsia risk by means of a prediction tool and counseled those with an above-population average risk on LDA as a prophylactic measure. Material and methods From 2017 to 2018, 865 women were recruited in multiple centers and prospectively followed using web-based surveys (Expect Study II). Rates and determinants of LDA usage among women with an increased preeclampsia risk in daily practice were assessed. Results were compared with findings in a similar cohort from a care-as-usual setting lacking risk-based counseling (Expect Study I, n = 2614). Netherlands Trial Register NTR4143. Results In total, 306 women had a predicted increased preeclampsia risk. LDA usage was higher for women receiving risk-based care than care-as-usual (29.4% vs 1.5%, odds ratio 19.1, 95% confidence interval 11.2-32.5). Daily LDA usage was positively correlated with both predicted risk and women's concerns regarding preeclampsia. Most reported reasons for non- or incomplete use were unawareness of LDA as a preventive intervention, concerns about potential adverse effects and doubts regarding the benefits. Conclusions Risk-based counseling was associated with a higher prevalence of LDA usage, but general usage rates were low. Future research regarding potential factors improving the usage of LDA during pregnancy is necessary.

Original languageEnglish
Pages (from-to)875-883
Number of pages9
JournalActa Obstetricia et Gynecologica Scandinavica
Issue number7
Publication statusPublished - Jul 2020


  • adherence
  • aspirin
  • preeclampsia
  • pregnancy

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