Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly

Joanna Brzeszczynska, Neil Johns, Alain Schilb, Simone Degen, Martin Degen, Ramon Langen, Annemie Schols, David J. Glass, Ronenn Roubenoff, Carolyn A. Greig, Carsten Jacobi, Kenneth C. H. Fearon, James A. Ross*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Web of Science)

Abstract

Muscle wasting in old age or cancer may result from failed myofiber regeneration and/or accelerated atrophy. This study aimed to determine from transcriptomic analysis of human muscle the integrity of the cellular stress response system in relation to satellite cell differentiation or apoptosis in patients with cancer (weight-stable (CWS) or weight-losing (CWL)) or healthy elderly (HE) when compared with healthy middle-aged controls (HMA). 28 patients with cancer (CWS: 18 and CWL: 10), HE: 21 and HMA: 20 underwent biopsy of quadriceps muscle. The expression of transcription factors for muscle regeneration (Pax3, Pax7 and MyoD) was increased in CWS and HE compared with HMA (p
Original languageEnglish
Pages (from-to)1690-1702
JournalAging
Volume8
Issue number8
DOIs
Publication statusPublished - Aug 2016

Keywords

  • cachexia
  • elderly
  • satellite cells
  • oxidative stress

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