@article{64f80236edbc4f8380b557fbef488097,
title = "Longitudinal follow-up of verbal span and processing speed in Duchenne muscular dystrophy",
abstract = "Neurocognitive deficits are frequently described in Duchenne muscular dystrophy (DMD), but it is unknown how these progress over time. Our aim was to longitudinally assess verbal span capacity and information processing speed in DMD and to explore a genotype-phenotype relation. Verbal span and processing speed scores were available of 28 males with DMD on two time-points, with a mean time interval of 28.34 months (SD = 16.09). The cohort contained of six patients missing only dystrophin isoform Dp427, sixteen missing Dp427 and Dp140, and six were undeterminable. A lower verbal span capacity was found at the first and second assessment, whereas processing speed was normal at both time-points. Post-hoc analyses suggested lower scores on verbal span and processing speed for patients missing Dp427 and Dp140. In DMD, a developmental stagnation in verbal span capacity, irrespective of normal processing speed, is detected through longitudinal follow-up. This appears more pronounced in patients missing Dp427 and Dp140. (C) 2020 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.",
keywords = "Duchenne muscular dystrophy, Longitudinal follow-up study, Cognition, Developmental stagnation, Genotype, Dystrophin isoforms, WORKING-MEMORY, NEUROPSYCHOLOGICAL PROFILE, BOYS, PERFORMANCE, CHILDREN, INTELLIGENCE, DEFICITS",
author = "Hellebrekers, {Danique M. J.} and Nathalie Doorenweerd and Sweere, {Dirk J. J.} and {van Kuijk}, {Sander M. J.} and Aartsma-Rus, {Annemieke M.} and Sylvia Klinkenberg and Vles, {Johan S. H.} and Hendriksen, {Jos G. M.}",
note = "Funding Information: The authors have stated that they had no interests which might be perceived as posing a conflict or bias. This work was supported by Spieren voor Spieren Foundation (JH.,SVS-15); Duchenne Parent Project NL (ND.,grant Brain imaging and cognition in Duchenne muscular dystrophy-2010); and Gratama Foundation (ND., grant number nr 10.13 ). The authors would like to thank all participants of Maastricht University Medical Center, the Leiden University Medical Centre and outpatient Centre of Neurological Learning disorders (CNL) of Kempenhaeghe, The Netherlands, and to Prof. dr. C.G. Faber, drs. J. Lionarons, prof. dr. J.J.G.M. Verschuuren, dr. E.H. Niks, and dr. H.E. Kan. Appendix A Funding Information: The authors have stated that they had no interests which might be perceived as posing a conflict or bias. This work was supported by Spieren voor Spieren Foundation (JH.SVS-15); Duchenne Parent Project NL (ND.grant Brain imaging and cognition in Duchenne muscular dystrophy-2010); and Gratama Foundation (ND. grant number nr 10.13). The authors would like to thank all participants of Maastricht University Medical Center, the Leiden University Medical Centre and outpatient Centre of Neurological Learning disorders (CNL) of Kempenhaeghe, The Netherlands, and to Prof. dr. C.G. Faber, drs. J. Lionarons, prof. dr. J.J.G.M. Verschuuren, dr. E.H. Niks, and dr. H.E. Kan. Publisher Copyright: {\textcopyright} 2020 European Paediatric Neurology Society; 23rd International Annual Congress of the World Muscle Society (WMS), WMS 2018 ; Conference date: 02-10-2018 Through 06-10-2018",
year = "2020",
month = mar,
doi = "10.1016/j.ejpn.2020.01.002",
language = "English",
volume = "25",
pages = "120--126",
journal = "European Journal of Paediatric Neurology",
issn = "1090-3798",
publisher = "ELSEVIER SCI LTD",
url = "http://www.wms2018.com/, http://www.wms2018.com/",
}