Longitudinal follow-up of verbal span and processing speed in Duchenne muscular dystrophy

Danique M. J. Hellebrekers*, Nathalie Doorenweerd, Dirk J. J. Sweere, Sander M. J. van Kuijk, Annemieke M. Aartsma-Rus, Sylvia Klinkenberg, Johan S. H. Vles, Jos G. M. Hendriksen

*Corresponding author for this work

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Abstract

Neurocognitive deficits are frequently described in Duchenne muscular dystrophy (DMD), but it is unknown how these progress over time. Our aim was to longitudinally assess verbal span capacity and information processing speed in DMD and to explore a genotype-phenotype relation. Verbal span and processing speed scores were available of 28 males with DMD on two time-points, with a mean time interval of 28.34 months (SD = 16.09). The cohort contained of six patients missing only dystrophin isoform Dp427, sixteen missing Dp427 and Dp140, and six were undeterminable. A lower verbal span capacity was found at the first and second assessment, whereas processing speed was normal at both time-points. Post-hoc analyses suggested lower scores on verbal span and processing speed for patients missing Dp427 and Dp140. In DMD, a developmental stagnation in verbal span capacity, irrespective of normal processing speed, is detected through longitudinal follow-up. This appears more pronounced in patients missing Dp427 and Dp140. (C) 2020 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)120-126
Number of pages7
JournalEuropean Journal of Paediatric Neurology
Volume25
DOIs
Publication statusPublished - Mar 2020
Event23rd International Annual Congress of the World Muscle Society (WMS) - Mendoza, ARGENTINA, Mendoza, Argentina
Duration: 2 Oct 20186 Oct 2018
Conference number: 23
http://www.wms2018.com/
http://www.wms2018.com/

Keywords

  • Duchenne muscular dystrophy
  • Longitudinal follow-up study
  • Cognition
  • Developmental stagnation
  • Genotype
  • Dystrophin isoforms
  • WORKING-MEMORY
  • NEUROPSYCHOLOGICAL PROFILE
  • BOYS
  • PERFORMANCE
  • CHILDREN
  • INTELLIGENCE
  • DEFICITS

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