Longitudinal changes in total and regional body composition in patients with chronic obstructive pulmonary disease

Felipe V. C. Machado; Martijn A. Spruit; Miranda Coenjaerds; Fabio Pitta; Niki L. Reynaert; Frits M. E. Franssen

doi:10.1111/resp.14100

Longitudinal changes in total and regional body composition in patients with chronic obstructive pulmonary disease

Felipe V. C. Machado^*, Martijn A. Spruit, Miranda Coenjaerds^*, Fabio Pitta, Niki L. Reynaert, Frits M. E. Franssen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background and objective Low fat-free mass (FFM) is common in patients with chronic obstructive pulmonary disease (COPD) and contributes to morbidity and mortality. Few studies have evaluated longitudinal changes in body composition in patients with COPD compared with non-COPD controls. This study aimed to compare longitudinal changes in total and regional body composition between patients with COPD and non-COPD controls and investigate predictors of changes in body composition in COPD.

Methods Patients with COPD and non-COPD controls participating in the Individualized COPD Evaluation in relation to Ageing (ICE-Age) study, a single-centre, longitudinal, observational study, were included. Subjects were assessed at baseline and after 2 years of follow-up. Among other procedures, body composition was measured by dual-energy X-ray absorptiometry scan. The number of exacerbations/hospitalizations 1 year before inclusion and during follow-up were assessed in patients with COPD.

Results A total of 405 subjects were included (205 COPD, 87 smoking and 113 non-smoking controls). Patients with COPD and smoking controls presented a significant decline in total FFM (mean [95% CI]: -1173 [-1527/-820] g and -486 [-816/-156] g, respectively) while body composition remained stable in non-smoking controls. In patients with COPD, the decline in FFM was more pronounced in legs (-174 [-361/14] g) and trunk (-675 [-944/406] g) rather than in arms (54 [-19/126] g). The predictors of changes in total and regional FFM in patients with COPD were gender, number of previous hospitalizations, baseline values of FFM and BMI.

Conclusion Patients with COPD present a significant decline in FFM after 2 years of follow-up, this decline is more pronounced in their legs and trunk.

Original language	English
Pages (from-to)	851-860
Number of pages	10
Journal	Respirology
Volume	26
Issue number	9
Early online date	15 Jun 2021
DOIs	https://doi.org/10.1111/resp.14100
Publication status	Published - Sept 2021

Keywords

body composition
chronic obstructive pulmonary disease
longitudinal change
low fat-free mass
physical activity
pulmonary rehabilitation
FAT-FREE MASS
SKELETAL-MUSCLE STRENGTH
SYSTEMIC INFLAMMATION
COPD
STANDARDIZATION
CLUSTERS
DECLINE
CAPACITY
WEAKNESS
SCALE

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Cite this

@article{305426515d2f4f97809e22227249e4f6,

title = "Longitudinal changes in total and regional body composition in patients with chronic obstructive pulmonary disease",

abstract = "Background and objective Low fat-free mass (FFM) is common in patients with chronic obstructive pulmonary disease (COPD) and contributes to morbidity and mortality. Few studies have evaluated longitudinal changes in body composition in patients with COPD compared with non-COPD controls. This study aimed to compare longitudinal changes in total and regional body composition between patients with COPD and non-COPD controls and investigate predictors of changes in body composition in COPD.Methods Patients with COPD and non-COPD controls participating in the Individualized COPD Evaluation in relation to Ageing (ICE-Age) study, a single-centre, longitudinal, observational study, were included. Subjects were assessed at baseline and after 2 years of follow-up. Among other procedures, body composition was measured by dual-energy X-ray absorptiometry scan. The number of exacerbations/hospitalizations 1 year before inclusion and during follow-up were assessed in patients with COPD.Results A total of 405 subjects were included (205 COPD, 87 smoking and 113 non-smoking controls). Patients with COPD and smoking controls presented a significant decline in total FFM (mean [95% CI]: -1173 [-1527/-820] g and -486 [-816/-156] g, respectively) while body composition remained stable in non-smoking controls. In patients with COPD, the decline in FFM was more pronounced in legs (-174 [-361/14] g) and trunk (-675 [-944/406] g) rather than in arms (54 [-19/126] g). The predictors of changes in total and regional FFM in patients with COPD were gender, number of previous hospitalizations, baseline values of FFM and BMI.Conclusion Patients with COPD present a significant decline in FFM after 2 years of follow-up, this decline is more pronounced in their legs and trunk.",

keywords = "body composition, chronic obstructive pulmonary disease, longitudinal change, low fat-free mass, physical activity, pulmonary rehabilitation, FAT-FREE MASS, SKELETAL-MUSCLE STRENGTH, SYSTEMIC INFLAMMATION, COPD, STANDARDIZATION, CLUSTERS, DECLINE, CAPACITY, WEAKNESS, SCALE",

author = "Machado, {Felipe V. C.} and Spruit, {Martijn A.} and Miranda Coenjaerds and Fabio Pitta and Reynaert, {Niki L.} and Franssen, {Frits M. E.}",

note = "Funding Information: Martijn A. Spruit reports grants from Netherlands Lung Foundation and Stichting Astma Bestrijding, and grants and personal fees from AstraZeneca and Boehringer Ingelheim, all outside the submitted work. Frits M. E. Franssen reports grants and personal fees from AstraZeneca and Novartis, and personal fees from Boehringer Ingelheim, Chiesi, GlaxoSmithKline and TEVA, outside the submitted work. The other authors declare that they have no conflicts of interest that could have influenced the present study. Funding Information: We are grateful to all subjects who were willing to participate in the current study. Research funding: Felipe V. C. Machado is financially supported by ZonMWAQ10 (ERACoSysMed grant #90030355). Publisher Copyright: {\textcopyright} 2021 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology.",

year = "2021",

month = sep,

doi = "10.1111/resp.14100",

language = "English",

volume = "26",

pages = "851--860",

journal = "Respirology",

issn = "1323-7799",

publisher = "Wiley",

number = "9",

}

TY - JOUR

T1 - Longitudinal changes in total and regional body composition in patients with chronic obstructive pulmonary disease

AU - Machado, Felipe V. C.

AU - Spruit, Martijn A.

AU - Coenjaerds, Miranda

AU - Pitta, Fabio

AU - Reynaert, Niki L.

AU - Franssen, Frits M. E.

N1 - Funding Information: Martijn A. Spruit reports grants from Netherlands Lung Foundation and Stichting Astma Bestrijding, and grants and personal fees from AstraZeneca and Boehringer Ingelheim, all outside the submitted work. Frits M. E. Franssen reports grants and personal fees from AstraZeneca and Novartis, and personal fees from Boehringer Ingelheim, Chiesi, GlaxoSmithKline and TEVA, outside the submitted work. The other authors declare that they have no conflicts of interest that could have influenced the present study. Funding Information: We are grateful to all subjects who were willing to participate in the current study. Research funding: Felipe V. C. Machado is financially supported by ZonMWAQ10 (ERACoSysMed grant #90030355). Publisher Copyright: © 2021 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology.

PY - 2021/9

Y1 - 2021/9

N2 - Background and objective Low fat-free mass (FFM) is common in patients with chronic obstructive pulmonary disease (COPD) and contributes to morbidity and mortality. Few studies have evaluated longitudinal changes in body composition in patients with COPD compared with non-COPD controls. This study aimed to compare longitudinal changes in total and regional body composition between patients with COPD and non-COPD controls and investigate predictors of changes in body composition in COPD.Methods Patients with COPD and non-COPD controls participating in the Individualized COPD Evaluation in relation to Ageing (ICE-Age) study, a single-centre, longitudinal, observational study, were included. Subjects were assessed at baseline and after 2 years of follow-up. Among other procedures, body composition was measured by dual-energy X-ray absorptiometry scan. The number of exacerbations/hospitalizations 1 year before inclusion and during follow-up were assessed in patients with COPD.Results A total of 405 subjects were included (205 COPD, 87 smoking and 113 non-smoking controls). Patients with COPD and smoking controls presented a significant decline in total FFM (mean [95% CI]: -1173 [-1527/-820] g and -486 [-816/-156] g, respectively) while body composition remained stable in non-smoking controls. In patients with COPD, the decline in FFM was more pronounced in legs (-174 [-361/14] g) and trunk (-675 [-944/406] g) rather than in arms (54 [-19/126] g). The predictors of changes in total and regional FFM in patients with COPD were gender, number of previous hospitalizations, baseline values of FFM and BMI.Conclusion Patients with COPD present a significant decline in FFM after 2 years of follow-up, this decline is more pronounced in their legs and trunk.

AB - Background and objective Low fat-free mass (FFM) is common in patients with chronic obstructive pulmonary disease (COPD) and contributes to morbidity and mortality. Few studies have evaluated longitudinal changes in body composition in patients with COPD compared with non-COPD controls. This study aimed to compare longitudinal changes in total and regional body composition between patients with COPD and non-COPD controls and investigate predictors of changes in body composition in COPD.Methods Patients with COPD and non-COPD controls participating in the Individualized COPD Evaluation in relation to Ageing (ICE-Age) study, a single-centre, longitudinal, observational study, were included. Subjects were assessed at baseline and after 2 years of follow-up. Among other procedures, body composition was measured by dual-energy X-ray absorptiometry scan. The number of exacerbations/hospitalizations 1 year before inclusion and during follow-up were assessed in patients with COPD.Results A total of 405 subjects were included (205 COPD, 87 smoking and 113 non-smoking controls). Patients with COPD and smoking controls presented a significant decline in total FFM (mean [95% CI]: -1173 [-1527/-820] g and -486 [-816/-156] g, respectively) while body composition remained stable in non-smoking controls. In patients with COPD, the decline in FFM was more pronounced in legs (-174 [-361/14] g) and trunk (-675 [-944/406] g) rather than in arms (54 [-19/126] g). The predictors of changes in total and regional FFM in patients with COPD were gender, number of previous hospitalizations, baseline values of FFM and BMI.Conclusion Patients with COPD present a significant decline in FFM after 2 years of follow-up, this decline is more pronounced in their legs and trunk.

KW - body composition

KW - chronic obstructive pulmonary disease

KW - longitudinal change

KW - low fat-free mass

KW - physical activity

KW - pulmonary rehabilitation

KW - FAT-FREE MASS

KW - SKELETAL-MUSCLE STRENGTH

KW - SYSTEMIC INFLAMMATION

KW - COPD

KW - STANDARDIZATION

KW - CLUSTERS

KW - DECLINE

KW - CAPACITY

KW - WEAKNESS

KW - SCALE

U2 - 10.1111/resp.14100

DO - 10.1111/resp.14100

M3 - Article

C2 - 34131996

SN - 1323-7799

VL - 26

SP - 851

EP - 860

JO - Respirology

JF - Respirology

IS - 9

ER -