Longitudinal changes in placental biomarkers in women with early versus late placental dysfunction

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Abstract

Objective: To evaluate longitudinal changes of angiogenic biomarkers in early- (EO-PD) versus late-onset (LO-PD) placental dysfunction. Methods: Serum PlGF and sFlt-1 measured at different intervals in EO-PD (n= 43), LO-PD (n= 31) and controls (n = 133). Results: sFlt-1/PlGF ratio was higher at 16 weeks (30.6 vs 17.5), 20 weeks (29.3 vs 8.9) and 30 weeks (16.6 vs 6.7) in EO-PD vs controls (all p<0.05), but not in LO-PD. Longitudinal changes for all intervals had higher AUC than single measurements. Conclusion: Longitudinal biomarker change between 12 and 30 weeks could improve prediction of EO-PD compared to single measurements.

Original languageEnglish
Pages (from-to)268-277
Number of pages10
JournalHypertension in Pregnancy
Volume38
Issue number4
DOIs
Publication statusPublished - 2 Oct 2019

Keywords

  • 36 WEEKS GESTATION
  • ANGIOGENIC FACTORS
  • ANTIANGIOGENIC FACTORS
  • EARLY-PREGNANCY
  • Early Pregnancy Complications
  • Eclampsia
  • Fetal Growth Restriction
  • HELLP
  • High-Risk Pregnancy
  • INTRAUTERINE GROWTH RESTRICTION
  • LATE-ONSET PREECLAMPSIA
  • PREDICT
  • Placenta
  • Preeclampsia
  • Pregnancy induced Hypertension
  • RISK
  • SOLUBLE ENDOGLIN
  • TYROSINE KINASE 1
  • ENDOTHELIAL GROWTH-FACTOR

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