Longitudinal changes in placental biomarkers in women with early versus late placental dysfunction

Manouk L. E. Hendrix; Kirsten C. M. Palm; Sander M. J. Van Kuijk; Otto Bekers; Marc E. A. Spaanderman; Judith A. P. Bons; Salwan Al-Nasiry

doi:10.1080/10641955.2019.1668948

Longitudinal changes in placental biomarkers in women with early versus late placental dysfunction

Manouk L. E. Hendrix^*, Kirsten C. M. Palm, Sander M. J. Van Kuijk, Otto Bekers, Marc E. A. Spaanderman, Judith A. P. Bons, Salwan Al-Nasiry

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objective: To evaluate longitudinal changes of angiogenic biomarkers in early- (EO-PD) versus late-onset (LO-PD) placental dysfunction. Methods: Serum PlGF and sFlt-1 measured at different intervals in EO-PD (n= 43), LO-PD (n= 31) and controls (n = 133). Results: sFlt-1/PlGF ratio was higher at 16 weeks (30.6 vs 17.5), 20 weeks (29.3 vs 8.9) and 30 weeks (16.6 vs 6.7) in EO-PD vs controls (all p<0.05), but not in LO-PD. Longitudinal changes for all intervals had higher AUC than single measurements. Conclusion: Longitudinal biomarker change between 12 and 30 weeks could improve prediction of EO-PD compared to single measurements.

Original language	English
Pages (from-to)	268-277
Number of pages	10
Journal	Hypertension in Pregnancy
Volume	38
Issue number	4
DOIs	https://doi.org/10.1080/10641955.2019.1668948
Publication status	Published - 2 Oct 2019

Keywords

36 WEEKS GESTATION
ANGIOGENIC FACTORS
ANTIANGIOGENIC FACTORS
EARLY-PREGNANCY
Early Pregnancy Complications
Eclampsia
Fetal Growth Restriction
HELLP
High-Risk Pregnancy
INTRAUTERINE GROWTH RESTRICTION
LATE-ONSET PREECLAMPSIA
PREDICT
Placenta
Preeclampsia
Pregnancy induced Hypertension
RISK
SOLUBLE ENDOGLIN
TYROSINE KINASE 1
ENDOTHELIAL GROWTH-FACTOR

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10.1080/10641955.2019.1668948

Full textFinal published version, 1.19 MBLicence: Taverne

Cite this

@article{9b4ed451c58e4bd88490ce1adf79131a,

title = "Longitudinal changes in placental biomarkers in women with early versus late placental dysfunction",

abstract = "Objective: To evaluate longitudinal changes of angiogenic biomarkers in early- (EO-PD) versus late-onset (LO-PD) placental dysfunction. Methods: Serum PlGF and sFlt-1 measured at different intervals in EO-PD (n= 43), LO-PD (n= 31) and controls (n = 133). Results: sFlt-1/PlGF ratio was higher at 16 weeks (30.6 vs 17.5), 20 weeks (29.3 vs 8.9) and 30 weeks (16.6 vs 6.7) in EO-PD vs controls (all p<0.05), but not in LO-PD. Longitudinal changes for all intervals had higher AUC than single measurements. Conclusion: Longitudinal biomarker change between 12 and 30 weeks could improve prediction of EO-PD compared to single measurements.",

keywords = "36 WEEKS GESTATION, ANGIOGENIC FACTORS, ANTIANGIOGENIC FACTORS, EARLY-PREGNANCY, Early Pregnancy Complications, Eclampsia, Fetal Growth Restriction, HELLP, High-Risk Pregnancy, INTRAUTERINE GROWTH RESTRICTION, LATE-ONSET PREECLAMPSIA, PREDICT, Placenta, Preeclampsia, Pregnancy induced Hypertension, RISK, SOLUBLE ENDOGLIN, TYROSINE KINASE 1, ENDOTHELIAL GROWTH-FACTOR",

author = "Hendrix, {Manouk L. E.} and Palm, {Kirsten C. M.} and {Van Kuijk}, {Sander M. J.} and Otto Bekers and Spaanderman, {Marc E. A.} and Bons, {Judith A. P.} and Salwan Al-Nasiry",

note = "Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2019",

month = oct,

day = "2",

doi = "10.1080/10641955.2019.1668948",

language = "English",

volume = "38",

pages = "268--277",

journal = "Hypertension in Pregnancy",

issn = "1064-1955",

publisher = "Routledge/Taylor & Francis Group",

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TY - JOUR

T1 - Longitudinal changes in placental biomarkers in women with early versus late placental dysfunction

AU - Hendrix, Manouk L. E.

AU - Palm, Kirsten C. M.

AU - Van Kuijk, Sander M. J.

AU - Bekers, Otto

AU - Spaanderman, Marc E. A.

AU - Bons, Judith A. P.

AU - Al-Nasiry, Salwan

PY - 2019/10/2

Y1 - 2019/10/2

N2 - Objective: To evaluate longitudinal changes of angiogenic biomarkers in early- (EO-PD) versus late-onset (LO-PD) placental dysfunction. Methods: Serum PlGF and sFlt-1 measured at different intervals in EO-PD (n= 43), LO-PD (n= 31) and controls (n = 133). Results: sFlt-1/PlGF ratio was higher at 16 weeks (30.6 vs 17.5), 20 weeks (29.3 vs 8.9) and 30 weeks (16.6 vs 6.7) in EO-PD vs controls (all p<0.05), but not in LO-PD. Longitudinal changes for all intervals had higher AUC than single measurements. Conclusion: Longitudinal biomarker change between 12 and 30 weeks could improve prediction of EO-PD compared to single measurements.

AB - Objective: To evaluate longitudinal changes of angiogenic biomarkers in early- (EO-PD) versus late-onset (LO-PD) placental dysfunction. Methods: Serum PlGF and sFlt-1 measured at different intervals in EO-PD (n= 43), LO-PD (n= 31) and controls (n = 133). Results: sFlt-1/PlGF ratio was higher at 16 weeks (30.6 vs 17.5), 20 weeks (29.3 vs 8.9) and 30 weeks (16.6 vs 6.7) in EO-PD vs controls (all p<0.05), but not in LO-PD. Longitudinal changes for all intervals had higher AUC than single measurements. Conclusion: Longitudinal biomarker change between 12 and 30 weeks could improve prediction of EO-PD compared to single measurements.

KW - 36 WEEKS GESTATION

KW - ANGIOGENIC FACTORS

KW - ANTIANGIOGENIC FACTORS

KW - EARLY-PREGNANCY

KW - Early Pregnancy Complications

KW - Eclampsia

KW - Fetal Growth Restriction

KW - HELLP

KW - High-Risk Pregnancy

KW - INTRAUTERINE GROWTH RESTRICTION

KW - LATE-ONSET PREECLAMPSIA

KW - PREDICT

KW - Placenta

KW - Preeclampsia

KW - Pregnancy induced Hypertension

KW - RISK

KW - SOLUBLE ENDOGLIN

KW - TYROSINE KINASE 1

KW - ENDOTHELIAL GROWTH-FACTOR

U2 - 10.1080/10641955.2019.1668948

DO - 10.1080/10641955.2019.1668948

M3 - Article

C2 - 31559879

SN - 1064-1955

VL - 38

SP - 268

EP - 277

JO - Hypertension in Pregnancy

JF - Hypertension in Pregnancy

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