@article{ca88efe4ded1463fbd777fdfa0ba4f55,
title = "Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment",
abstract = "We investigated longitudinal associations of moderate-to-vigorous physical activity (MVPA) and light-intensity physical activity (LPA) with plasma concentrations of 138 metabolites after colorectal cancer (CRC) treatment. Self-reported physical activity data and blood samples were obtained at 6 weeks, and 6, 12 and 24 months post-treatment in stage I-III CRC survivors (n=252). Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQp180 kit). Linear mixed models were used to evaluate confounder-adjusted longitudinal associations. Inter-individual (between-participant differences) and intra-individual associations (within-participant changes over time) were assessed as percentage difference in metabolite concentration per 5 h/week of MVPA or LPA. At 6 weeks post-treatment, participants reported a median of 6.5 h/week of MVPA (interquartile range:2.3,13.5) and 7.5 h/week of LPA (2.0,15.8). Inter-individual associations were observed with more MVPA being related (FDR-adjusted q-value",
keywords = "QUALITY-OF-LIFE, TARGETED METABOLOMICS, HEALTH, SERUM, REPRODUCIBILITY, CLASSIFICATION, QUESTIONNAIRE, BIOMARKERS, SIGNATURES, MORTALITY",
author = "\{van Roekel\}, \{Eline H.\} and Bours, \{Martijn J. L.\} and \{van Delden\}, Linda and Breukink, \{Stephanie O.\} and Michel Aquarius and Keulen, \{Eric T. P.\} and Audrey Gicquiau and Vivian Viallon and Sabina Rinaldi and Paolo Vineis and Arts, \{Ilja C. W.\} and Gunter, \{Marc J.\} and Leitzmann, \{Michael F.\} and Augustin Scalbert and Weijenberg, \{Matty P.\}",
note = "Funding Information: We would like to thank all participants of the EnCoRe study and the health professionals in the three hospitals involved in the recruitment of participants of the study: Maastricht University Medical Centre+, VieCuri Medical Center, and Zuyderland Medical Centre. We would also like to thank the MEMIC center for data and information management for facilitating the logistic processes and data management of our study. Finally, we would like to thank the research dieticians and research assistant who are responsible for patient inclusion and follow-up, performing home visits, as well as data collection and processing. This study was funded by the Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme (Grant No. 2016/1620). The EnCoRe study is also funded by grants from the Stichting Alpe d{\textquoteright}HuZes within the research program {\textquoteright}Leven met kanker{\textquoteright} of the Dutch Cancer Society (Grant No. UM-2010-4867 and UM-2012-5653), by grants from Kankeronderzoekfonds Limburg as part of Health Foundation Limburg (Grant No. 00005739) and by a grant of the Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme (Grant No. 2017/1619). E.H. van Roekel is funded by the Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme (Grant No. 2016/1620). Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = jul,
day = "2",
doi = "10.1038/s41598-021-92279-9",
language = "English",
volume = "11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Research",
number = "1",
}