Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment

Eline H. van Roekel*, Martijn J. L. Bours, Linda van Delden, Stephanie O. Breukink, Michel Aquarius, Eric T. P. Keulen, Audrey Gicquiau, Vivian Viallon, Sabina Rinaldi, Paolo Vineis, Ilja C. W. Arts, Marc J. Gunter, Michael F. Leitzmann, Augustin Scalbert, Matty P. Weijenberg

*Corresponding author for this work

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Abstract

We investigated longitudinal associations of moderate-to-vigorous physical activity (MVPA) and light-intensity physical activity (LPA) with plasma concentrations of 138 metabolites after colorectal cancer (CRC) treatment. Self-reported physical activity data and blood samples were obtained at 6 weeks, and 6, 12 and 24 months post-treatment in stage I-III CRC survivors (n=252). Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQp180 kit). Linear mixed models were used to evaluate confounder-adjusted longitudinal associations. Inter-individual (between-participant differences) and intra-individual associations (within-participant changes over time) were assessed as percentage difference in metabolite concentration per 5 h/week of MVPA or LPA. At 6 weeks post-treatment, participants reported a median of 6.5 h/week of MVPA (interquartile range:2.3,13.5) and 7.5 h/week of LPA (2.0,15.8). Inter-individual associations were observed with more MVPA being related (FDR-adjusted q-value

Original languageEnglish
Article number13738
Number of pages14
JournalScientific Reports
Volume11
Issue number1
DOIs
Publication statusPublished - 2 Jul 2021

Keywords

  • QUALITY-OF-LIFE
  • TARGETED METABOLOMICS
  • HEALTH
  • SERUM
  • REPRODUCIBILITY
  • CLASSIFICATION
  • QUESTIONNAIRE
  • BIOMARKERS
  • SIGNATURES
  • MORTALITY

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