Long-term update of the 24954 EORTC phase III trial on larynx preservation

B. Henriques De Figueiredo; C. Fortpied; J. Menis; Jean-Louis Lefebvre; Luigi Barzan; D. de Raucourt; L. Geoffrois; L. Giurgea; P. Hupperets; René C Leemans; Lisa Licitra; F. Rolland; M.E. Tesselaar; J B. Vermorken; Vincent Gregoire

doi:10.1016/j.ejca.2016.06.024

Long-term update of the 24954 EORTC phase III trial on larynx preservation

B. Henriques De Figueiredo^*, C. Fortpied, J. Menis, Jean-Louis Lefebvre, Luigi Barzan, D. de Raucourt, L. Geoffrois, L. Giurgea, P. Hupperets, René C Leemans, Lisa Licitra, F. Rolland, M.E. Tesselaar, J B. Vermorken, Vincent Gregoire

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The long-term results of the EORTC 24954 trial comparing sequential versus alternating chemotherapy and radiotherapy (RT) for patients with locally advanced laryngeal and hypopharyngeal cancer are reported. From 1996 to 2004, 450 patients were randomly assigned (1–1) to a sequential arm (SA = induction cisplatin-5fluorouracil followed by a 70Gy-RT for the responders or a total laryngectomy and post-operative RT for the non-responders) and an alternating arm (AA = cisplatin-5fluorouracil alternated with three 2-week courses of 20 Gy-RT for a total dose of 60 Gy). Median follow-up was 10.2 years. Ten-year survival with functional larynx (primary end-point) and overall survival were similar in both arms (18.7% and 33.6% in SA versus 18.3% and 31.6% in AA). Late toxicity was also similar; however, a trend for higher larynx preservation and better laryngeal function was observed in AA.

Original language	English
Pages (from-to)	109-112
Number of pages	4
Journal	European Journal of Cancer
Volume	65
DOIs	https://doi.org/10.1016/j.ejca.2016.06.024
Publication status	Published - Sept 2016

Keywords

Larynx preservation
Radiochemotherapy
Late toxicity

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10.1016/j.ejca.2016.06.024

Cite this

De Figueiredo, B. H., Fortpied, C., Menis, J., Lefebvre, J.-L., Barzan, L., de Raucourt, D., Geoffrois, L., Giurgea, L., Hupperets, P., Leemans, R. C., Licitra, L., Rolland, F., Tesselaar, M. E., Vermorken, J. B., & Gregoire, V. (2016). Long-term update of the 24954 EORTC phase III trial on larynx preservation. European Journal of Cancer, 65, 109-112. https://doi.org/10.1016/j.ejca.2016.06.024

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title = "Long-term update of the 24954 EORTC phase III trial on larynx preservation",

abstract = "The long-term results of the EORTC 24954 trial comparing sequential versus alternating chemotherapy and radiotherapy (RT) for patients with locally advanced laryngeal and hypopharyngeal cancer are reported. From 1996 to 2004, 450 patients were randomly assigned (1–1) to a sequential arm (SA = induction cisplatin-5fluorouracil followed by a 70Gy-RT for the responders or a total laryngectomy and post-operative RT for the non-responders) and an alternating arm (AA = cisplatin-5fluorouracil alternated with three 2-week courses of 20 Gy-RT for a total dose of 60 Gy). Median follow-up was 10.2 years. Ten-year survival with functional larynx (primary end-point) and overall survival were similar in both arms (18.7% and 33.6% in SA versus 18.3% and 31.6% in AA). Late toxicity was also similar; however, a trend for higher larynx preservation and better laryngeal function was observed in AA.",

keywords = "Larynx preservation, Radiochemotherapy, Late toxicity",

author = "{De Figueiredo}, {B. Henriques} and C. Fortpied and J. Menis and Jean-Louis Lefebvre and Luigi Barzan and {de Raucourt}, D. and L. Geoffrois and L. Giurgea and P. Hupperets and Leemans, {Ren{\'e} C} and Lisa Licitra and F. Rolland and M.E. Tesselaar and Vermorken, {J B.} and Vincent Gregoire",

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De Figueiredo, BH, Fortpied, C, Menis, J, Lefebvre, J-L, Barzan, L, de Raucourt, D, Geoffrois, L, Giurgea, L, Hupperets, P, Leemans, RC, Licitra, L, Rolland, F, Tesselaar, ME, Vermorken, JB & Gregoire, V 2016, 'Long-term update of the 24954 EORTC phase III trial on larynx preservation', European Journal of Cancer, vol. 65, pp. 109-112. https://doi.org/10.1016/j.ejca.2016.06.024

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AU - De Figueiredo, B. Henriques

AU - Fortpied, C.

AU - Menis, J.

AU - Lefebvre, Jean-Louis

AU - Barzan, Luigi

AU - de Raucourt, D.

AU - Geoffrois, L.

AU - Giurgea, L.

AU - Hupperets, P.

AU - Leemans, René C

AU - Licitra, Lisa

AU - Rolland, F.

AU - Tesselaar, M.E.

AU - Vermorken, J B.

AU - Gregoire, Vincent

PY - 2016/9

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N2 - The long-term results of the EORTC 24954 trial comparing sequential versus alternating chemotherapy and radiotherapy (RT) for patients with locally advanced laryngeal and hypopharyngeal cancer are reported. From 1996 to 2004, 450 patients were randomly assigned (1–1) to a sequential arm (SA = induction cisplatin-5fluorouracil followed by a 70Gy-RT for the responders or a total laryngectomy and post-operative RT for the non-responders) and an alternating arm (AA = cisplatin-5fluorouracil alternated with three 2-week courses of 20 Gy-RT for a total dose of 60 Gy). Median follow-up was 10.2 years. Ten-year survival with functional larynx (primary end-point) and overall survival were similar in both arms (18.7% and 33.6% in SA versus 18.3% and 31.6% in AA). Late toxicity was also similar; however, a trend for higher larynx preservation and better laryngeal function was observed in AA.

AB - The long-term results of the EORTC 24954 trial comparing sequential versus alternating chemotherapy and radiotherapy (RT) for patients with locally advanced laryngeal and hypopharyngeal cancer are reported. From 1996 to 2004, 450 patients were randomly assigned (1–1) to a sequential arm (SA = induction cisplatin-5fluorouracil followed by a 70Gy-RT for the responders or a total laryngectomy and post-operative RT for the non-responders) and an alternating arm (AA = cisplatin-5fluorouracil alternated with three 2-week courses of 20 Gy-RT for a total dose of 60 Gy). Median follow-up was 10.2 years. Ten-year survival with functional larynx (primary end-point) and overall survival were similar in both arms (18.7% and 33.6% in SA versus 18.3% and 31.6% in AA). Late toxicity was also similar; however, a trend for higher larynx preservation and better laryngeal function was observed in AA.

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KW - Radiochemotherapy

KW - Late toxicity

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