Long-term safety of withholding standard prophylaxis in patients with moderate chronic kidney disease

E.C. Nijssen*, P.J. Nelemans, R.J. Rennenberg, G.V. van Ommen, J.E. Wildberger

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In the latest ESUR contrast media guidelines, standard prophylaxis is no longer recommended for patients with moderate chronic kidney disease (CKD). In the absence of solid evidence, guideline updates are often based on indirect evidence and expert opinion. Likewise, evidence supporting the withdrawal of standard prophylaxis in moderate CKD patients was scarce and mostly indirect, but did include one randomised controlled trial evaluating guideline-recommended standard prophylactic intravenous hydration against a group receiving no prophylaxis (A MAastricht Contrast-Induced Nephropathy Guideline (AMACING) trial). Since then, benefits of the updated guideline recommendation for patient and hospital burden have been numerated and were shown to be substantial. The current special report provides data on long-term safety from the AMACING randomised controlled trial.
Original languageEnglish
Pages (from-to)627-632
Number of pages6
JournalEuropean Radiology
Volume33
Issue number1
Early online date28 Jun 2022
DOIs
Publication statusPublished - Jan 2023

Keywords

  • Contrast media
  • Acute kidney injury
  • Chronic kidney disease
  • Prophylaxis
  • Clinical practice guidelines
  • IODINATED CONTRAST MATERIAL
  • PROTECT RENAL-FUNCTION
  • HYDRATION
  • RISK

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